Management of hypotension in dihydropyridine calcium channel blocker overdose: The role of high-dose insulin therapy. [PDF]
Br J Clin PharmacolChan BSH +3 more
europepmc +1 more source
Advanced Science, EarlyView.Advanced delivery systems—including nanoparticles, nanoemulsions, liposomes, and hydrogels—protect food‐derived bioactive peptides from gastrointestinal degradation and bitterness. These systems enable pH‐responsive release, enhance intestinal absorption, and improve therapeutic efficacy against oxidative stress, metabolic disorders, cancer, and ...
Yu Xu +5 more
wiley +1 more source
Impact of intensive insulin therapy on dynamic cardiac function in critically ill patients with stress-induced hyperglycemia. [PDF]
World J DiabetesWang YD, Yu JJ.
europepmc +1 more source
Advanced Science, EarlyView.Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon +6 more
wiley +1 more source
Swimming exercise reversed the loss of grip strength, muscle cross-sectional area and trabecular bone volume among type 1 diabetic rats independent of insulin therapy. [PDF]
Int J Clin Exp PatholLi X +9 more
europepmc +1 more source
Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies
Advanced Science, EarlyView.This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang +7 more
wiley +1 more source
Real world evidence of insulin and biosimilar insulin therapy-Opportunities to improve adherence, outcomes and cost-effectiveness. [PDF]
Diabetes Obes MetabYang A +4 more
europepmc +1 more source
Advanced Science, EarlyView.Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong +10 more
wiley +1 more source
Efficacy and safety of needle-free injection in patients with type 2 diabetes mellitus undergoing intensive insulin therapy: a randomized controlled trial based on the flash glucose monitoring system. [PDF]
Front Endocrinol (Lausanne)Wang J +12 more
europepmc +1 more source
Advanced Science, EarlyView.Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen +6 more
wiley +1 more source