Results 61 to 70 of about 14,705 (155)

Acute tetraparesis in a labrador retriever with suspected ectopic insulinoma and paraneoplastic polyneuropathy

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Summary This case report describes a 10‐year‐old, male, neutered labrador retriever that was presented with acute non‐ambulatory tetraparesis, later diagnosed with an ectopic insulinoma and paraneoplastic polyneuropathy. Clinical evaluation revealed severe hypoglycaemia, generalised neuromuscular signs and electromyography findings were consistent with
Laryssa Straub, Janet Kovak McClaran, Emma Laws, Ana Garcia Fernandez   +3 more
wiley   +1 more source

Unmasked insulinoma occasioned by severe hypoglycemic coma immediately postpartum: a case report

BMC Endocrine Disorders, 2023
Background Insulinoma in women during pregnancy and postpartum is very rare; approximately 65% of cases are diagnosed early in pregnancy and ~ 35% immediately after delivery, few being found in middle or late pregnancy, likely due to increased insulin ...
Kiyoshi Matsumoto, Miyu Watanabe, Ken Takao, Hirokazu Takahashi, Hisashi Daido, Toshiro Shibata, Tokuyuki Hirose, Takehiro Kato, Masami Mizuno, Takuo Hirota, Tetsuya Suwa, Yukio Horikawa, Takaaki Murakami, Daisuke Yabe   +13 more
doaj   +1 more source

Pancreatic Neuroendocrine Tumor Leading to a Diagnosis of Multiple Endocrine Neoplasia Type 1

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Pancreatic neuroendocrine neoplasms are rare but occasionally encountered. They are generally highly vascularized solid tumors, often round in shape with clear boundaries, defined contours, and a homogeneous internal structure. However, they can also present with atypical features, such as cystic degeneration, hemorrhage, calcification, and ...
Noriyuki Hirakawa, Katsuya Kitamura, Kei Yamamoto, Kenichi Tadokoro, Yasunosuke Akita, Jun Uemura, Fumito Yamanishi, Masakazu Abe, Munehide Nakatsugawa, Takao Itoi   +9 more
wiley   +1 more source

Endogenous hyperinsulinism: diagnostic and therapeutic difficulties

The Pan African Medical Journal, 2019
Endogenous hyperinsulinism is an abnormal clinical condition that involves excessive insulin secretion, related in 55% of cases to insulinoma. Other causes are possible such as islet cell hyperplasia, nesidioblastosis or antibodies to insulin or to the ...
Esma Leila Gouta, Hichem Jerraya, Wejih Dougaz, Mohamed Ali Chaouech, Ibtissem Bouasker, Ramzi Nouira, Chadly Dziri   +6 more
doaj   +1 more source

A case of insulinoma with hypoglycemia that was better managed with lanreotide than octreotide

Clinical Case Reports, 2021
Long‐acting somatostatin analogs, including lanreotide slow release (LAN‐SR) and octreotide long‐acting release (OCT‐LAR), can improve hypoglycemia in insulinoma. LAN‐SR may be more beneficial in some patients with insulinoma than OCT‐LAR.
Keiko Yamaoka, Shuichi Nagashima, Nobukazu Okada, Nagisa Sawayama, Shinsuke Saito, Manabu Takahashi, Kenta Okada, Kazuhiro Endo, Masaru Koizumi, Hideki Sasanuma, Ken Ebihara, Atsuko Kasajima, Noriyoshi Fukushima, Naohiro Sata, Shun Ishibashi   +14 more
doaj   +1 more source

Microbiome‐Based Clustering Identifies Glycemic Control‐Related Subtypes in Youth With Recent‐Onset Type 1 Diabetes

MedComm, Volume 7, Issue 4, April 2026.
Microbiome‐based clustering investigated possible glycemic control‐related endotypes in youth with recent‐onset T1D, and found a potential role of Bacteroides and skatole production in glycemic control. This study offers novel perspectives on the influence of intestinal microbes and its metabolites in T1D heterogeneity and lays a foundation for future ...
Huiling Tan, Yu Ding, Zhaohe Gu, Xulin Wang, Jing Wang, Tian Wei, Xiaoya Zhang, Lanxin Pan, Yu Shi, Shiru Chang, Chuang Guo, Jianping Weng, Xueying Zheng, Tong Yue   +13 more
wiley   +1 more source

Dapansutrile preserves pancreatic beta‐cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3054-3069, April 2026.
Abstract Aims/Hypothesis Pancreatic beta‐cell dysfunction is pivotal in diabetes pathogenesis, with the NOD‐like receptor protein 3 (NLRP3) inflammasome playing a crucial role. Dapansutrile (DAPA), a novel NLRP3 inhibitor, demonstrates promise in diabetes management.
Ying Wu, Hongxing Fu, Min Zhu, Yuanfa Yao, Luhong Jin, Xihua Lin, Jiaqiang Zhou   +6 more
wiley   +1 more source

Insulinoma in Patients with Diabetes- A Systematic Review of Previously Reported Cases

Indian Journal of Endocrinology and Metabolism
Introduction: Paradoxical co-existence of insulinoma and diabetes is extremely rare. Although a few case reports addressed this association, a comprehensive study elucidating this relationship has been lacking.
Subhankar Chatterjee, Rana Bhattacharjee, Ritwik Ghosh, Partha P. Chakraborty, Anirban Sinha, Animesh Maiti   +5 more
doaj   +1 more source

Effect of metformin on pancreatic neuroendocrine tumors of multiple endocrine neoplasia type 1

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract Metformin is a widely prescribed medication in the management of type 2 diabetes mellitus, and numerous epidemiological studies have indicated an association between metformin use and a reduced risk of certain cancers in diabetic populations. However, evidence supporting a role for metformin in cancer prevention remains inconclusive. Exploring
Serguei V. Kozlov, Sunita K. Agarwal, Theresa M. Guerin, Wendi Custer Lawrence, Laura L. Bassel, Akua Graf, Smita Jha, Lee S. Weinstein, Jenny E. Blau, Jaydira del Rivero   +9 more
wiley   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, Volume 16, Issue 3, Page 520-531, March 2026.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source