Results 61 to 70 of about 34,184 (259)

Insulinoma with focal hepatic lesions: malignant insulinoma? [PDF]

BMJ Case Reports, 2015
Insulinoma is a rare tumour that is malignant in only 10% of cases. We report a case of insulinoma in a 59-year-old woman, associated with focal liver lesions, which raised the suspicion of malignancy of a pancreatic tumour. Enucleation of the insulinoma was performed with wedge resection of one hepatic nodule.
Yossra Zidi-Mouaffek, Hichem Jerraya, Safi Dokmak, Chadli Dziri   +3 more
openaire   +3 more sources

Pancreatic Neuroendocrine Tumor Leading to a Diagnosis of Multiple Endocrine Neoplasia Type 1

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Pancreatic neuroendocrine neoplasms are rare but occasionally encountered. They are generally highly vascularized solid tumors, often round in shape with clear boundaries, defined contours, and a homogeneous internal structure. However, they can also present with atypical features, such as cystic degeneration, hemorrhage, calcification, and ...
Noriyuki Hirakawa, Katsuya Kitamura, Kei Yamamoto, Kenichi Tadokoro, Yasunosuke Akita, Jun Uemura, Fumito Yamanishi, Masakazu Abe, Munehide Nakatsugawa, Takao Itoi   +9 more
wiley   +1 more source

Heterogeneity of proliferative markers in pancreatic β-cells of patients with severe hypoglycemia following Roux-en-Y gastric bypass. [PDF]

, 2017
Severe postprandial hypoglycemia with neuroglycopenia is an increasingly recognized, debilitating complication of Roux-en-Y gastric bypass (RYGB) surgery.
Folli, F., Goldfine, A.B., Goldsmith, J., Hoem, D., Hu, J., Kulkarni, R.N., La Rosa, S., Molven, A., Patti, M.E., Schwesinger, W.H.   +9 more
core   +2 more sources

Pancreatic Intraductal Papillary Mucinous Neoplasm With Invasive Carcinoma Concomitant With Ampullary Neuroendocrine Tumor: A Case Report

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT This case reports a rare co‐occurrence of pancreatic intraductal papillary mucinous neoplasm with invasive carcinoma and ampullary neuroendocrine tumor. Laparoscopic pancreaticoduodenectomy was done. No recurrence/metastasis in 12‐month follow‐up, though both tumors had lymph node metastasis, warranting attention to timely biopsy.
Jingcheng Zhang, Jianhao Huang, Xiaodong He, Mengqing Sun, Xianlin Han   +4 more
wiley   +1 more source

A case of insulinoma with hypoglycemia that was better managed with lanreotide than octreotide

Clinical Case Reports, 2021
Long‐acting somatostatin analogs, including lanreotide slow release (LAN‐SR) and octreotide long‐acting release (OCT‐LAR), can improve hypoglycemia in insulinoma. LAN‐SR may be more beneficial in some patients with insulinoma than OCT‐LAR.
Keiko Yamaoka, Shuichi Nagashima, Nobukazu Okada, Nagisa Sawayama, Shinsuke Saito, Manabu Takahashi, Kenta Okada, Kazuhiro Endo, Masaru Koizumi, Hideki Sasanuma, Ken Ebihara, Atsuko Kasajima, Noriyoshi Fukushima, Naohiro Sata, Shun Ishibashi   +14 more
doaj   +1 more source

Combined biological therapy with lanreotide autogel and cabergoline in the treatment of MEN-1-related insulinomas. [PDF]

, 2014
Multiple endocrine neoplasia type 1 (MEN1) is a hereditary syndrome associated with the development of many endocrine tumors, involving mainly pituitary, parathyroids, pancreas, although a proliferative state interests all neuroendocrine system.
Camera, L, Carratù, A, Colao, A, de Luca di Roseto, C, Del Prete, M, Di Somma, C, Faggiano, A., Marciello, F, Marotta, V, Ramundo, V   +9 more
core   +1 more source

Insulinoma in Patients with Diabetes- A Systematic Review of Previously Reported Cases

Indian Journal of Endocrinology and Metabolism
Introduction: Paradoxical co-existence of insulinoma and diabetes is extremely rare. Although a few case reports addressed this association, a comprehensive study elucidating this relationship has been lacking.
Subhankar Chatterjee, Rana Bhattacharjee, Ritwik Ghosh, Partha P. Chakraborty, Anirban Sinha, Animesh Maiti   +5 more
doaj   +1 more source

Endogenous hyperinsulinism: diagnostic and therapeutic difficulties

The Pan African Medical Journal, 2019
Endogenous hyperinsulinism is an abnormal clinical condition that involves excessive insulin secretion, related in 55% of cases to insulinoma. Other causes are possible such as islet cell hyperplasia, nesidioblastosis or antibodies to insulin or to the ...
Esma Leila Gouta, Hichem Jerraya, Wejih Dougaz, Mohamed Ali Chaouech, Ibtissem Bouasker, Ramzi Nouira, Chadly Dziri   +6 more
doaj   +1 more source

Unmasked insulinoma occasioned by severe hypoglycemic coma immediately postpartum: a case report

BMC Endocrine Disorders, 2023
Background Insulinoma in women during pregnancy and postpartum is very rare; approximately 65% of cases are diagnosed early in pregnancy and ~ 35% immediately after delivery, few being found in middle or late pregnancy, likely due to increased insulin ...
Kiyoshi Matsumoto, Miyu Watanabe, Ken Takao, Hirokazu Takahashi, Hisashi Daido, Toshiro Shibata, Tokuyuki Hirose, Takehiro Kato, Masami Mizuno, Takuo Hirota, Tetsuya Suwa, Yukio Horikawa, Takaaki Murakami, Daisuke Yabe   +13 more
doaj   +1 more source

OTUB1 Modulates Ferroptosis by Regulating SLC7A11 Ubiquitination in Pancreatic β‐Cells

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
2‐Deoxy‐d‐ribose (dRib) suppresses OTUB1 expression in pancreatic β‐cells, reducing its ability to stabilize SLC7A11 (xCT). Loss of OTUB1 enhances SLC7A11 ubiquitination and proteasomal degradation, leading to impaired cystine uptake, glutathione depletion, and ferroptotic cell death.
Soyeon Yoo, Dongkyu Kim, Miyeon Kim, Ju Young Bae, Sang Ah Lee, Eui Tae Kim, Gwanpyo Koh   +6 more
wiley   +1 more source