Results 91 to 100 of about 5,388,871 (377)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Expansive mappings on bounded sets and their application to rational integral equations [PDF]
, 2020 Nicolae Adrian Secelean +1 more
openalex +1 more source
An Integral of the Two-Dimensional Stationary Viscous Fluid Flow Equations [PDF]
, 2021 D. V. Knyazev
openalex +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Fredholm-Volterra integral equation with potential kernel
International Journal of Mathematics and Mathematical Sciences, 2001 A method is used to solve the Fredholm-Volterra integral equation of the first kind in the space L2(Ω)×C(0,T), Ω={(x,y):x2+y2≤a}, z=0, and ...
M. A. Abdou, A. A. El-Bary
doaj +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Archives of Acoustics, 2014 In this paper, the authors propose an algorithm for numerical solution of the 3D Helmholtz equation using the Parametric Integral Equation System (PIES). The PIES, unlike the traditional Boundary Integral Equation (BIE), is characterized by the fact that
E. ZIENIUK, K. SZERSZEŃ
doaj
Constructive method for solvability of Fredholm equation of the first kind
Electronic Journal of Qualitative Theory of Differential Equations, 2017 The solvability and construction of the general solution of the first kind Fredholm integral equation are among the insufficiently explored problems in mathematics. There are various approaches to solve this problem.
Serikbai Aisagaliev, Zhanat Zhunussova
doaj +1 more source
Numerical scheme of fractional differential-integral equations in three-dimensional spaces via block-pulse functions [PDF]
, 2022 Wei Shi +3 more
openalex +1 more source