Results 91 to 100 of about 4,481,393 (334)

Numerical Solution of Multiple Nonlinear Volterra Integral Equations [PDF]

open access: yesarXiv, 2008
We analyze a discretization method for solving nonlinear integral equations that contain multiple integrals. These equations include integral equations with a Volterra series, instead of a single integral term, on one side of the equation. We prove existence and uniqueness of solutions, and convergence and estimates of the order of convergence for the ...
arxiv  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

An Integral Equation for Feynman's Operational Calcului [PDF]

open access: yesIntegration: Mathematical Theory and Applications, 1 (2008), 49-66, 2009
In this paper we develop an integral equation satisfied by Feynman's operational calculi in formalism of B. Jefferies and G. W. Johnson. In particular a "reduced" disentangling is derived and an evolution equation of DeFacio, Johnson, and Lapidus is used to obtain the integral equation.
arxiv  

An integral equation approach to boundary value problems of classical elastostatics

open access: yes, 1967
The analogy between potential theory and classical elasticity suggests an extension of the powerful method of integral equations to the boundary value problems of elasticity.
F. Rizzo
semanticscholar   +1 more source

A Hybrid Volume-Surface Integral Equation Method for Rapid Electromagnetic Simulations in MRI. [PDF]

open access: yesIEEE Trans Biomed Eng, 2023
Giannakopoulos II   +8 more
europepmc   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Some new nonlinear integral inequalities and their applications in the qualitative analysis of differential equations

open access: yesJournal of Inequalities and Applications, 2011
In this paper, some new nonlinear integral inequalities are established, which provide a handy tool for analyzing the global existence and boundedness of solutions of differential and integral equations.
Zheng Bin, Feng Qinghua
doaj  

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