Results 101 to 110 of about 1,319,197 (338)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Fredholm-Volterra integral equation with potential kernel

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2001
A method is used to solve the Fredholm-Volterra integral equation of the first kind in the space L2(Ω)×C(0,T), Ω={(x,y):x2+y2≤a}, z=0, and ...
M. A. Abdou, A. A. El-Bary
doaj   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

A Hybrid Volume-Surface Integral Equation Method for Rapid Electromagnetic Simulations in MRI. [PDF]

open access: yesIEEE Trans Biomed Eng, 2023
Giannakopoulos II   +8 more
europepmc   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

Smoothed integral equations

open access: yesJournal of Mathematical Analysis and Applications, 2011
AbstractFor a linear integral equation x(t)=a(t)−∫0tB(t,s)x(s)ds there is a resolvent equation R(t,s)=B(t,s)−∫stB(t,u)R(u,s)du and a variation of parameters formula x(t)=a(t)−∫0tR(t,s)a(s)ds. It is assumed that B is a perturbed convex function and that a(t) may be badly behaved in several ways.
Theodore Burton, D. P. Dwiggins
openaire   +2 more sources

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