Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Some properties of the functional equation ϕ(x)=f(x)+∫0λxg(x,y,ϕ(y))dy
International Journal of Mathematics and Mathematical Sciences, 1991 A discussion is given of some of the properties of the functional Volterra Integral equation ϕ(x)=f(x)+∫0λxg(x,y,ϕ(y))dy. and of the corresponding multidimensional equation.
Li. G. Chambers
doaj +1 more source
Angle-dependent integral equation theory improves results of thermodynamics and structure of rose water model. [PDF]
J Chem Phys, 2023 Ogrin P, Urbic T.
europepmc +1 more source
On the numerical solution of a boundary integral equation for the exterior Neumann problem on domains with corners [PDF]
, 2015 Luisa Fermo, C. Laurita
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A Hybrid Volume-Surface Integral Equation Method for Rapid Electromagnetic Simulations in MRI. [PDF]
IEEE Trans Biomed Eng, 2023 Giannakopoulos II +8 more
europepmc +1 more source
Oscillation Criteria for Functional Dynamic Equations with Nonlinearities Given by Riemann-Stieltjes Integral [PDF]
, 2014 Yuangong Sun, Taher S. Hassan
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Synthesis of the parameters of the elastic-damping device in the excavator’s digging mechanism based on the use of the integral equation [PDF]
, 2021 Nikolay Kuznetsov, I A Iov, E.S. Dolgih
openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source