Results 81 to 90 of about 1,350,314 (331)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Integral equation theory for nematic fluids

Condensed Matter Physics, 2010
The traditional formalism in liquid state theory based on the calculation of the pair distribution function is generalized and reviewed for nematic fluids. The considered approach is based on the solution of orientationally inhomogeneous Ornstein-Zernike
M.F. Holovko
doaj   +1 more source

On the solvability of the scalar monochromatic wave diffraction problem on an inhomogeneous solid with specific transmission conditions

Известия высших учебных заведений. Поволжский регион: Физико-математические науки, 2023
Background. The purpose of this work is to study the 3-D scalar problem of scattering a plane wave from an inhomogeneous solid covered with an infinitely thin layer of graphene. Material and methods.
Aleksey A. Tsupak
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

An Algorithm for the Solution of Integro-Fractional Differential Equations with a Generalized Symmetric Singular Kernel

Fractal and Fractional
This work studies an integro-fractional differential equation (I-FrDE) with a generalized symmetric singular kernel. The scientific approach in this study was to transform the integro-differential equation (I-DE) into a mixed integral equation (MIE) with
Sameeha A. Raad, Mohammed A. Abdou
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Fredholm-Volterra integral equation with potential kernel

International Journal of Mathematics and Mathematical Sciences, 2001
A method is used to solve the Fredholm-Volterra integral equation of the first kind in the space L2(Ω)×C(0,T), Ω={(x,y):x2+y2≤a}, z=0, and ...
M. A. Abdou, A. A. El-Bary
doaj   +1 more source

Constructive method for solvability of Fredholm equation of the first kind

Electronic Journal of Qualitative Theory of Differential Equations, 2017
The solvability and construction of the general solution of the first kind Fredholm integral equation are among the insufficiently explored problems in mathematics. There are various approaches to solve this problem.
Serikbai Aisagaliev, Zhanat Zhunussova
doaj   +1 more source