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Multimodal Functionalities of HIV-1 Integrase
Viruses, 2022 Integrase is the retroviral protein responsible for integrating reverse transcripts into cellular genomes. Co-packaged with viral RNA and reverse transcriptase into capsid-encased viral cores, human immunodeficiency virus 1 (HIV-1) integrase has long ...
Alan N. Engelman, Mamuka Kvaratskhelia
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Structure and function of retroviral integrase [PDF]
Nature Reviews Microbiology, 2021 A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the viral enzyme responsible for the catalytic steps involved in this process, and integrase strand transfer inhibitors are widely used to treat people living with HIV ...
G. Maertens, A. Engelman, P. Cherepanov
semanticscholar +5 more sources
Weight gain and integrase inhibitors. [PDF]
Current Opinion in Infectious Diseases, 2019 PURPOSE OF REVIEW Weight gain and obesity among people living with HIV (PLWH) is a serious problem that occurs often after initiation of antiretroviral therapy but may be worse with integrase strand transfer inhibitors (INSTIs).
A. Eckard, G. McComsey
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Substrate specificity of Ty1 integrase [PDF]
Journal of Virology, 1995 Integration of the Saccharomyces cerevisiae retrotransposon Ty1 requires the element-encoded integrase (IN) protein, which is a component of cytoplasmic virus-like particles (VLPs). Using purified recombinant Ty1 IN and an oligonucleotide integration assay based on Ty1 long terminal repeat sequences, we have compared IN activity on substrates having ...
S P Moore +2 more
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mBio, 2017 Resistance to the integrase strand transfer inhibitors raltegravir and elvitegravir is often due to well-identified mutations in the integrase gene. However, the situation is less clear for patients who fail dolutegravir treatment.
Isabelle Malet +7 more
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Prophage Integrase Typing Is a Useful Indicator of Genomic Diversity in Salmonella enterica
Frontiers in Microbiology, 2017 Salmonella enterica is a bacterial species that is a major cause of illness in humans and food-producing animals. S. enterica exhibits considerable inter-serovar diversity, as evidenced by the large number of host adapted serovars that have been ...
Anna Colavecchio +11 more
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Scientific Reports, 2017 Human Ku70/Ku80 protein is known to influence HIV-1 replication. One of the possible reasons may be the protection of integrase from proteasomal degradation by Ku70 subunit. We demonstrated that recombinant HIV-1 integrase and Ku70 form a stable complex,
Andrey N. Anisenko +6 more
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Prototype Foamy Virus Integrase Displays Unique Biochemical Activities among Retroviral Integrases [PDF]
Biomolecules, 2021 Integrases of different retroviruses assemble as functional complexes with varying multimers of the protein. Retroviral integrases require a divalent metal cation to perform one-step transesterification catalysis.
Anthony J. Rabe +3 more
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Variable orthogonality of serine integrase interactions within the ϕC31 family [PDF]
Scientific ReportsSerine integrases are phage- (or mobile element-) encoded enzymes that catalyse site-specific recombination reactions between a short DNA sequence on the phage genome (attP) and a corresponding host genome sequence (attB), thereby integrating the phage ...
Alasdair I. MacDonald +6 more
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An integrase toolbox to record gene-expression during plant development
bioRxiv, 2022 Synthetic circuits that can record in vivo signaling networks is critical in elucidating developmental process. Here, the authors describe the engineering and application of synthetic in vivo recorders with different promoters that can drive ...
Sarah Guiziou +3 more
semanticscholar +1 more source