Results 1 to 10 of about 57,554 (268)

Multimodal Functionalities of HIV-1 Integrase

Viruses, 2022
Integrase is the retroviral protein responsible for integrating reverse transcripts into cellular genomes. Co-packaged with viral RNA and reverse transcriptase into capsid-encased viral cores, human immunodeficiency virus 1 (HIV-1) integrase has long ...
Alan N. Engelman, Mamuka Kvaratskhelia
doaj   +2 more sources

Mutations Located outside the Integrase Gene Can Confer Resistance to HIV-1 Integrase Strand Transfer Inhibitors

mBio, 2017
Resistance to the integrase strand transfer inhibitors raltegravir and elvitegravir is often due to well-identified mutations in the integrase gene. However, the situation is less clear for patients who fail dolutegravir treatment.
Isabelle Malet, Frédéric Subra, Charlotte Charpentier, Gilles Collin, Diane Descamps, Vincent Calvez, Anne-Geneviève Marcelin, Olivier Delelis   +7 more
doaj   +2 more sources

Characterization of HIV-1 integrase interaction with human Ku70 protein and initial implications for drug targeting

Scientific Reports, 2017
Human Ku70/Ku80 protein is known to influence HIV-1 replication. One of the possible reasons may be the protection of integrase from proteasomal degradation by Ku70 subunit. We demonstrated that recombinant HIV-1 integrase and Ku70 form a stable complex,
Andrey N. Anisenko, Ekaterina S. Knyazhanskaya, Artur O. Zalevsky, Julia Yu Agapkina, Aleksander I. Sizov, Timofey S. Zatsepin, Marina B. Gottikh   +6 more
doaj   +2 more sources

Prophage Integrase Typing Is a Useful Indicator of Genomic Diversity in Salmonella enterica

Frontiers in Microbiology, 2017
Salmonella enterica is a bacterial species that is a major cause of illness in humans and food-producing animals. S. enterica exhibits considerable inter-serovar diversity, as evidenced by the large number of host adapted serovars that have been ...
Anna Colavecchio, Yasmin D’Souza, Elizabeth Tompkins, Julie Jeukens, Luca Freschi, Jean-Guillaume Emond-Rheault, Irena Kukavica-Ibrulj, Brian Boyle, Sadjia Bekal, Sandeep Tamber, Roger C. Levesque, Lawrence D. Goodridge   +11 more
doaj   +2 more sources

An integrase toolbox to record gene-expression during plant development

bioRxiv, 2022
Synthetic circuits that can record in vivo signaling networks is critical in elucidating developmental process. Here, the authors describe the engineering and application of synthetic in vivo recorders with different promoters that can drive ...
Sarah Guiziou, Cassandra J. Maranas, J. Chu, J. Nemhauser   +3 more
semanticscholar   +1 more source

Dual Long-Acting Cabotegravir/Rilpivirine Plus Lenacapavir in Integrase Strand Transfer Inhibitor Resistance: A Case Report and Review of the Literature [PDF]

Open Forum Infect Dis
Lillian M. Seo, Brenna Reilly-Evans, Joseph Garland   +2 more
europepmc   +2 more sources

Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs

Viruses, 2021
Integrase strand transfer inhibitors (INSTIs) are currently recommended for the first line treatment of human immunodeficiency virus type one (HIV-1) infection. The first-generation INSTIs are effective but can select for resistant viruses.
Steven J. Smith, X. Zhao, D. Passos, D. Lyumkis, T. Burke, S. Hughes   +5 more
semanticscholar   +1 more source

Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding Inhibitor. [PDF]

PLoS ONE, 2015
Understanding the HIV integrase protein and mechanisms of resistance to HIV integrase inhibitors is complicated by the lack of a full length HIV integrase crystal structure. Moreover, a lentiviral integrase structure with co-crystallised DNA has not been
Peter K Quashie, Ying-Shan Han, Said Hassounah, Thibault Mesplède, Mark A Wainberg   +4 more
doaj   +1 more source

Emergence of Resistance in HIV-1 Integrase with Dolutegravir Treatment in a Pediatric Population from the IMPAACT P1093 Study

Antimicrobial Agents and Chemotherapy, 2021
P1093 is a multicenter, open-label, phase I/II study of pharmacokinetics, safety, and tolerability of dolutegravir plus an optimized background regimen in pediatric participants aged 4 weeks to
C. Vavro, T. Ruel, A. Wiznia, Nicole Montañez, Keith Nangle, Joseph H Horton, A. Buchanan, E. Stewart, P. Palumbo   +8 more
semanticscholar   +1 more source

Novel Mobile Integrons and Strain-Specific Integrase Genes within Shewanella spp. Unveil Multiple Lateral Genetic Transfer Events within The Genus

Microorganisms, 2022
Shewanella spp. are Gram-negative bacteria that thrive in aquatic niches and also can cause infectious diseases as opportunistic pathogens. Chromosomal (CI) and mobile integrons (MI) were previously described in some Shewanella isolates.
Teolincacihuatl Ayala Nuñez, Gabriela N. Cerbino, María Florencia Rapisardi, Cecilia Quiroga, Daniela Centrón   +4 more
doaj   +1 more source