Results 91 to 100 of about 75,567 (173)
Retrotransposon Tto1: functional analysis and engineering for insertional mutagenesis [PDF]
, 2011 Retrotransposons are genomic parasites activated by stress conditions that can be seriously detrimental for their host. In this work I demonstrate that Tto1, a typical plant LTR retrotransposon with insertion preference into genes can be turned into a ...
Tramontano, Andrea +2 more
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Angiotensin II Type 1 Receptor Blocker Usage Prevents Oxidative Stress and Muscle Dysfunction in HIV
Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.ABSTRACT Background We aimed to elucidate the role of Angiotensin II type 1 receptor (AT1R) blocker usage in muscle wasting and dysfunction related to HIV. Research Design and Methods Appendicular skeletal muscle mass, higher and lower limb strength, and physical fitness were determined in people living with HIV (PWH) using AT1R blockers users (n = 33),
Rafael Deminice +4 more
wiley +1 more source
Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis
eLife, 2019 ABSTRACTA large number of HIV-1 integrase (IN) alterations, referred to as class II substitutions, exhibit pleotropic effects during virus replication. However, the underlying mechanism for the class II phenotype is not known. Here we demonstrate that all tested class II IN substitutions compromised IN-RNA binding in virions by one of three distinct ...
Elliott, Jennifer +9 more
openaire +6 more sources
Obesity Reviews, Volume 26, Issue 7, July 2025.Summary HIV remains a significant health concern, but the advent of antiretroviral therapy (ART) has transformed it into a manageable chronic condition. However, weight gain and obesity pose a substantial challenge for people living with HIV (PLWH). Moreover, the role of lifestyle has not yet been comprehensively investigated.
Giulia Gilberti +5 more
wiley +1 more source
A Bacterial Sulfotransferase Catalyzes an Unusual Di‐Sulfation in Natural Products Biosynthesis
ChemBioChem, Volume 26, Issue 11, June 3, 2025.Herein, a unique sulfotransferase, AdpST, is identified from the adp biosynthetic gene clusters (BGC) in Streptomyces davaonensis DSM101723 and demonstrates that AdpST possesses di‐sulfation activity, which is unprecedented for bacterial phosphoadenosine‐5’‐phosphosulfate (PAPS)‐dependent sulfotransferases. It is further shown that the adp BGC contains
Conor Pulliam +5 more
wiley +1 more source
The Complex Role of CD8+ T Cells in Placental HIV Infection
European Journal of Immunology, Volume 55, Issue 6, June 2025.CD8+ T cells exhibit dual roles at the maternal‐fetal interface supporting tolerance via IL‐10 and TGF‐β and aiding implantation and vascular remodeling through TNF‐α and IFN‐γ. In HIV infection, CD8+ T cells expand, driving inflammation, PD‐L1 upregulation on trophoblasts, and cytotoxic dysfunction via reduced Granzyme B and Perforin, compromising ...
Kimberly Peta +2 more
wiley +1 more source
Journal of the International AIDS Society, Volume 28, Issue 6, June 2025.Abstract Introduction Data on drug resistance, viral outcomes and guidelines compliance following protease inhibitor (PI)‐based second‐line failure in low‐ and middle‐income countries are limited, particularly in the era of dolutegravir‐containing antiretroviral therapy (ART). Methods We conducted a retrospective cohort study of people living with HIV (
John M. Humphrey +11 more
wiley +1 more source
Environmental Microbiology Reports, Volume 17, Issue 3, June 2025.Following a 3.5‐year enrichment cultivation period, a rapid‐growing ammonia‐oxidising archaeon, designated CL1T, was isolated from the East China Sea. Strain CL1T represents a new species within the Nitrosarchaeum genus and is capable of effectively oxidising ammonia at both low and high concentrations through the GS‐GOGAT and GDH pathways. Furthermore,
Hailing Li +7 more
wiley +1 more source
Significance of constitutive integrase synthesis. [PDF]
Proceedings of the National Academy of Sciences, 1976 One conceivable function for constitutive integrase formation by lambda prophage is to stabilize the inserted state by catalyzing reinsertion of prophages that are accidentally excised. As this hypothesis implies a dynamic equilibrium betwen inserted and noninserted DNA, the existence of such an equilibrium is explored.
openaire +3 more sources
Characterization and expression analysis of Staphylococcus aureus pathogenicity island 3 - Implications for the evolution of staphylococcal pathogenicity islands [PDF]
, 2002 We describe the complete sequence of the 15.9-kb staphylococcal pathogenicity island 3 encoding staphylococcal enterotoxin serotypes B, K, and Q. The island, which meets the generally accepted definition of pathogenicity islands, contains 24 open reading
Kapur, Vivek +5 more
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