Results 91 to 100 of about 54,271 (286)

Resistance to inhibitors of the human immunodeficiency virus type 1 integration

Brazilian Journal of Infectious Diseases, 2010
This review will summarize the role of integrase in HIV-1 infection, the mechanism of integrase inhibitors and resistance with an emphasis on raltegravir (RAL), the first integrase inhibitor licensed to treat HIV-1 infection.
Daria J. Hazuda, PhD
doaj  

Classification of Tangle Solutions for Integrases, A Protein Family that Changes DNA Topology [PDF]

arXiv, 2005
Integrase proteins acting on circular double-stranded DNA often change its topology by transforming unknotted circles into torus knots and links. Two systems of tangle equations--corresponding to the two initial DNA sequences--arise when modelling this transformation: direct and inverted.
arxiv  

Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase

PLoS Biology, 2016
The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV ...
Kushol Gupta, Vesa Turkki, S. Sherrill-Mix, Y. Hwang, Grant Eilers, Louis J. Taylor, C. McDanal, Ping Wang, D. Temelkoff, R. Nolte, E. Velthuisen, J. Jeffrey, G. V. Van Duyne, F. Bushman   +13 more
semanticscholar   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors.

Journal of Antimicrobial Chemotherapy, 2016
OBJECTIVES Dolutegravir shows a high barrier to resistance with no previously reported cases of acquired integrase mutations during first-line therapy.
B. Brenner, Réjean Thomas, J. Blanco, Ruxandra-Ilinca Ibanescu, Maureen Oliveira, T. Mesplède, Olga Golubkov, M. Roger, Federico García, E. Martinez, M. Wainberg   +10 more
semanticscholar   +1 more source

Multifunctional facets of retrovirus integrase

World Journal of Biological Chemistry, 2015
The retrovirus integrase (IN) is responsible for integration of the reverse transcribed linear cDNA into the host DNA genome. First, IN cleaves a dinucleotide from the 3' OH blunt ends of the viral DNA exposing the highly conserved CA sequence in the recessed ends.
Sibes Bera, Hideki Aihara, Duane P. Grandgenett, Krishan K. Pandey   +3 more
openaire   +3 more sources

Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF‐16

The FEBS Journal, EarlyView.
To investigate the impact of dietary components on animal growth, an Escherichia coli single‐gene deletion library was screened using the Caenorhabditis elegans growth model. Thirty‐four E. coli mutants were identified to delay worm development. Notably, E.
Min Feng, Baizhen Gao, L. Rene Garcia, Qing Sun   +3 more
wiley   +1 more source

DNA insertion mutations can be predicted by a periodic probability function [PDF]

arXiv, 2017
It is generally difficult to predict the positions of mutations in genomic DNA at the nucleotide level. Retroviral DNA insertion is one mode of mutation, resulting in host infections that are difficult to treat. This mutation process involves the integration of retroviral DNA into the host-infected cellular genomic DNA following the interaction between
arxiv  

High‐risk human papillomavirus prevalence and serostatus in a cohort of cisgender women and people with a cervix living with perinatally acquired HIV

HIV Medicine, EarlyView.
Abstract Objectives Human papillomavirus (HPV)‐associated cervical cancer risk is greater in people with HIV, although this has been at least partially attenuated by antiretroviral medication, enhanced cervical screening and HPV vaccination. People with perinatally acquired HIV may remain at higher risk due to lifelong immunosuppression and potentially
Merle Henderson, Dierdre Lyons, Simon Beddows, Miranda Cowen, Kavita Panwar, Corrina Wright, Jacquie Ujetz, Ellie Crook, Hasit Patel, David Smith, Caroline Foster, Sarah Fidler, Tamara Elliott   +12 more
wiley   +1 more source

Hamming distance geometry of a protein conformational space. Application to the clustering of a 4 ns molecular dynamics trajectory of the HIV-1 integrase catalytic core [PDF]

PROTEINS: Structure, Function, and Genetics 47, 169-179 (2002), 2001
Protein structures can be encoded into binary sequences, these are used to define a Hamming distance in conformational space: the distance between two different molecular conformations is the number of different bits in their sequences. Each bit in the sequence arises from a partition of conformational space in two halves. Thus, the information encoded
arxiv