Results 91 to 100 of about 10,041 (223)

Multifunctional facets of retrovirus integrase

World Journal of Biological Chemistry, 2015
The retrovirus integrase (IN) is responsible for integration of the reverse transcribed linear cDNA into the host DNA genome. First, IN cleaves a dinucleotide from the 3' OH blunt ends of the viral DNA exposing the highly conserved CA sequence in the recessed ends.
Duane P, Grandgenett, Krishan K, Pandey, Sibes, Bera, Hideki, Aihara   +3 more
openaire   +2 more sources

Opportunities and Challenges for Surveillance of Congenital Anomalies in Sub‐Saharan Africa

Birth Defects Research, Volume 118, Issue 6, June 2026.
ABSTRACT Introduction Congenital anomalies (CA) are ranked as the 3rd and 4th leading cause of neonatal and under‐5 mortality, respectively. Over 30% of infants born with a serious CA are found in sub‐Saharan Africa. Yet there are few robust epidemiological data on the burden and distribution of CA and associated mortality, disability, and morbidity ...
Emma Kalk, Helen Louise Malherbe, Ushma C. Mehta, Daniel Mumpe‐Mwanja, Modiegi Dianah Diseko, Adejumoke Idowu Ayede, Phyllis Kisa, Caroline Bonareri Osoro, George Bello, Lee Fairlie, Audrey Chepkemoi, Hamisi K. Shabani, Ali Sie, Samrawit Abebaw Tegene, Robert Serunjogi, Aminkeng Zawuo Leke, Helen Dolk, Linda Barlow Mosha, on behalf of the sub‐Saharan African Congenital Anomalies Network (sSCAN)   +18 more
wiley   +1 more source

A long journey towards genome editing technologies in plants: a technical and critical review of genome editing technologies

Frontiers in Genome Editing
Advancements in genome editing technologies, notably CRISPR/Cas9, base editing (BE), and prime editing (PE), have revolutionized plant biotechnology, offering unprecedented precision in crop improvement to address the ongoing global warming challenge ...
Dylan Gallo, Anne-Cécile Meunier, Christophe Périn   +2 more
doaj   +1 more source

Target DNA bending by the Mu transpososome promotes careful transposition and prevents its reversal

eLife, 2017
The transposition of bacteriophage Mu serves as a model system for understanding DDE transposases and integrases. All available structures of these enzymes at the end of the transposition reaction, including Mu, exhibit significant bends in the ...
James R Fuller, Phoebe A Rice
doaj   +1 more source

The Chemical Structures, Neuroprotective Effects, Structure–Activity Relationships, and Applications of Flavonoids, Phenolic Acids, Terpenoids, and Sterols in Dandelion: A Review

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This review systematically summarizes the chemical structures and structure–activity relationships of key bioactive compounds in dandelion, including flavonoids, phenolic acids, terpenoids, and sterols. It highlights their neuroprotective mechanisms against neuroinflammation and oxidative stress, while outlining their promising dual applications in the
Hongye Li, Bingchan Qu, Jiasu Wu, Menghan Sun, Youlin Xue, Tiejing Li, Chang Tan, Shan Wang, Chong Ning, Chongting Guo   +9 more
wiley   +1 more source

Tanglegram of host species lineages and phylogeny of serine integrases in prophages and ICEs.

, 2019
A tanglegram of serine integrases from ICEs and prophages with the species lineages plotted on the left and tyrosine integrase phylogeny plotted on the right. Connections are drawn between a species and the serine integrase(s) found in that species.
Andrew Brantley Hall (8119820), Xiaofang Jiang (3799252), Eric J. Alm (7485080), Ramnik J. Xavier (153776)   +3 more
core   +1 more source

Antimicrobial Resistance and Virulence in Escherichia coli from Broiler Production Unit: Genetic Insights for One Health

Medical Sciences Forum
The overuse of antibiotics in livestock contributes to antimicrobial resistance and zoonotic risk. This study investigated 19 Escherichia coli isolates from broiler feces (Savinor, Portugal), characterizing resistance genes, virulence factors, integrases,
Jessica Ribeiro, Vanessa Silva, Gilberto Igrejas, Sandrina A. Heleno, Filipa S. Reis, Patrícia Poeta   +5 more
doaj   +1 more source

A Global Health Alert on the Re‐Emergence of Mpox a Viral Zoonotic Illness Its Prevention and Management: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Monkeypox virus (MPXV) is gaining attention in the global health community due to its potential for human transmission and similarities to the well‐known smallpox virus. Mpox was first detected in the 1970s and mostly affects Central and West Africa.
Muslim Bin Aqeel, Asif Hanif, Shahzad Ahmad, Fatima Iftikhar Shah, Benish Javed, Shazia Iqbal   +5 more
wiley   +1 more source

Tanglegram of host species lineages and phylogeny of the integrases in prophages and ICEs.

, 2019
A tanglegram of tyrosine integrases from ICEs and prophages with the species lineages plotted on the left and tyrosine integrase phylogeny plotted on the right.
Andrew Brantley Hall (8119820), Xiaofang Jiang (3799252), Eric J. Alm (7485080), Ramnik J. Xavier (153776)   +3 more
core   +1 more source

Timely and Efficient Infant Diagnosis Is Required to End AIDS in Children

Journal of the International AIDS Society, Volume 29, Issue S1, June 2026.
ABSTRACT Introduction Though considerable effort and investment has significantly increased the proportion of pregnant women living with HIV accessing lifesaving antiretroviral therapy and lowered the prevalence of vertical HIV transmission, more than 70,000 children die each year due to AIDS‐related deaths, and nearly half of the 1.4 million children ...
Lara Vojnov, Ilesh V. Jani
wiley   +1 more source