Results 101 to 110 of about 10,041 (223)

Integron-encoded IntI integrases preferentially recognize the adjacent cognate attI site in recombination with a 59-be site.

, 2002
Integrons have the capacity to capture small mobile elements known as gene cassettes, and this reaction is catalysed by integron-encoded IntI integrases.
Mi‐Jurng Kim, Kim, M-J, Ruth M. Hall, Christina M. Collis, Hall, RM, Collis, CM, H. W. Stokes, Stokes, HW   +7 more
core   +1 more source

The SSV1 viral integrase is not essential

Virology, 2007
Viral integration is a widely conserved characteristic in viruses in all domains of life; however, its necessity is not well understood in many cases. Integration using tyrosine recombinases is one of the most widespread and best characterized mechanisms of integration. We completely removed the tyrosine recombinase integrase from the hyperthermophilic
Clore, Adam J., Stedman, Kenneth M.
openaire   +2 more sources

Baseline Data on Viral Suppression, Treatment Adherence and Mental Health in Peripartum Girls and Young Women With HIV in Zimbabwe

Journal of the International AIDS Society, Volume 29, Issue S1, June 2026.
ABSTRACT Introduction Peripartum adolescent girls and young women (AGYW) with HIV have lower viral suppression compared to older women. But the recently introduced dolutegravir‐based regimens and psychosocial peer motivation may improve viral control.
Tariro D. Chawana‐Mutingwende, Bernard Ngara, Leon‐Say Mudadi, Thelma T. Tauya, Marvelous Sibanda, Mercy Mutambanengwe‐Jacob, Precious Andifasi, Bernadette Malunda, Tinashe Chidemo, Annie Mapfunde, Sandra Nyakudya, Anna Z. Mufumisi, Thandiwe H. Chirenda, Tobias Chitambo, Walter T. S. Nderecha, Constance Murandu, Miriam Gwande, Kudakwashe Muringayi, Rhoda Micah Bongo, Hideaki Okochi, Karen Kuncze, Angela Mushavi, Nicola Willis, Karen Webb, Monica Gandhi, Lynda Stranix‐Chibanda   +25 more
wiley   +1 more source

Nucleosome DNA unwrapping does not affect prototype foamy virus integration efficiency or site selection.

PLoS ONE, 2019
Eukaryotic DNA binding proteins must access genomic DNA that is packaged into chromatin in vivo. During a productive infection, retroviral integrases (IN) must similarly interact with chromatin to integrate the viral cDNA genome. Here we examine the role
Randi M Mackler, Nathan D Jones, Anne M Gardner, Miguel A Lopez, Cecil J Howard, Richard Fishel, Kristine E Yoder   +6 more
doaj   +1 more source

The site-specific integration reaction of Listeria phage A118 integrase, a serine recombinase

Mobile DNA, 2013
Background A large subfamily of serine recombinases contains long polypeptide segments appended to the C-terminal end of the conserved catalytic domain.
Mandali Sridhar, Dhar Gautam, Avliyakulov Nuraly K, Haykinson Michael J, Johnson Reid C   +4 more
doaj   +1 more source

Cause of Death and Risk of Death for People Living With HIV Admitted to Hospital: A Systematic Review and Meta‐Analysis

Journal of the International AIDS Society, Volume 29, Issue 6, June 2026.
ABSTRACT Introduction Despite increasing access to HIV treatment and care, HIV‐associated deaths remain high. We aimed to summarize global and regional trends in risk and causes of death among people living with HIV (PLHIV) admitted to hospital. Methods We conducted a systematic search across eight databases on 23 April 2023, identifying studies that ...
Rachael M. Burke, Nadia Sabet, Jayne Ellis, Hannah M. Rickman, Ajay Rangaraj, David S. Lawrence, Joseph N. Jarvis, Jane Falconer, Lillian Tugume, Rebecca H. Berhanu, Nathan Ford, Peter MacPherson   +11 more
wiley   +1 more source

A novel family of tyrosine integrases encoded by the temperate pleolipovirus SNJ2

, 2018
International audienceGenomes of halophilic archaea typically contain multiple loci of integrated mobile genetic elements (MGEs). Despite the abundance of these elements, however, mechanisms underlying their site-specific integration and excision have ...
Jiao Wang, Yuchen Wang, Mart Krupovic, Wang, Jiao, Ying Liu, Liu, Yingchun, Du, Kaixin, Kaixin Du, Xiangdong Chen, Liu, Ying, Wang, Yuchen, Yingchun Liu, Xu, Shuqi, Krupovic, Mart, Chen, Xiangdong, Shuqi Xu   +15 more
core   +1 more source

Genome‐Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Mathilde Duque, Aymeric Jacquemin, Delphine Girlich, Rémy A. Bonnin, Laurent Dortet   +4 more
wiley   +1 more source

Accuracy and efficiency define Bxb1 integrase as the best of fifteen candidate serine recombinases for the integration of DNA into the human genome [PDF]

, 2013
Background: Phage-encoded serine integrases, such as φC31 integrase, are widely used for genome engineering. Fifteen such integrases have been described but their utility for genome engineering has not been compared in uniform assays.
Smith, Maggie, William Brown, Xu, Z, Xu, Zhengyao, Zhengyao Xu, Louise Thomas, Ronald Chalmers, Chalmers, R, Chalmers, Ronald, Maggie Smith, Brown, W, Davies, Ben, Thomas, Louise, Brown, William, Thomas, L, Ben Davies, Smith, M, Davies, B   +17 more
core   +1 more source

Unveiling Marine Vesicle Uptake in Vibrio spp: Taxonomic and Environmental Insights

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Extracellular vesicles are involved in diverse functions in nature from microbial interactions to pathogenesis. Here, we investigate whether taxonomy represents a boundary that constrains the uptake of vesicles between different marine bacteria including ubiquitous Vibrio spp. involved in marine organism diseases, such as corals.
Nadefa Adda Nekrouf, Lucia Maestre‐Carballa, Monica Lluesma‐Gomez, Esther Rubio‐Portillo, Manuel Martinez‐Garcia   +4 more
wiley   +1 more source