Results 131 to 140 of about 31,694 (314)

Target DNA bending by the Mu transpososome promotes careful transposition and prevents its reversal

eLife, 2017
The transposition of bacteriophage Mu serves as a model system for understanding DDE transposases and integrases. All available structures of these enzymes at the end of the transposition reaction, including Mu, exhibit significant bends in the ...
James R Fuller, Phoebe A Rice
doaj   +1 more source

Emergence of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump Conferring Resistance to Multiple Drugs, Including Tigecycline, in Klebsiella pneumoniae

mBio, 2020
Transporters belonging to the chromosomally encoded resistance-nodulation-division (RND) superfamily mediate multidrug resistance in Gram-negative bacteria.
Luchao Lv, Miao Wan, Chengzhen Wang, Xun Gao, Qiwen Yang, Sally R. Partridge, Yang Wang, Zhiyong Zong, Yohei Doi, Jianzhong Shen, Peiyao Jia, Qianhua Song, Qianhui Zhang, Jun Yang, Xianhui Huang, Minggui Wang, Jian-Hua Liu   +16 more
doaj   +1 more source

Draft Genome Sequence of Mycobacterium arupense Strain GUC1. [PDF]

, 2015
We report the draft genome sequence of Mycobacterium arupense strain GUC1 from a sputum sample of a patient with bronchiectasis.
Chiu, Charles Y, Cunningham, Gail, Greninger, Alexander L, Hsu, Elaine D, Miller, Steve, Yu, Joanna M   +5 more
core   +2 more sources

Long‐acting injectable cabotegravir and rilpivirine in observational cohort studies: A systematic review on virological failure, resistance and re‐suppression outcomes in virally suppressed individuals living with HIV

HIV Medicine, EarlyView.
Abstract Introduction Randomized controlled trial evidence suggests that long‐acting injectable (LA‐I) cabotegravir and rilpivirine (CAB+RPV) has similar virological failure (VF) rates to daily oral therapy, but clinical practice evidence is lacking. Integrase inhibitor (INI) resistance may limit future therapy.
Kyle Ring, Alexa Elias, Megan Devonald, Melanie Smuk, Chloe Orkin   +4 more
wiley   +1 more source

Generation of Site-Specific Retargeting Platform Cell Lines for Drug Discovery Using phiC31 and R4 Integrases

Journal of biomolecular screening, 2009
One of the challenges in developing cell lines for high-throughput screening in drug discovery is the labor- and time-intensive process required to create stable clonal cell lines that express specific reporters or drug targets.
P. Lieu, T. Machleidt, B. Thyagarajan, Andrew Fontes, Elizabeth Frey, M. Fuerstenau-Sharp, D. Thompson, Geetha M. Swamilingiah, Suchitra S. Derebail, David R. Piper, J. Chesnut   +10 more
semanticscholar   +1 more source

Factors mediating and associated with immunological response in women living with HIV in Sweden: A nationwide register‐based study

HIV Medicine, EarlyView.
Abstract Introduction Women remain underrepresented in studies on immunological response (IR) among virally suppressed people living with HIV. Despite receiving antiretroviral therapy (ART) some individuals do not attain an IR, increasing their risk of non‐AIDS morbidity and mortality.
Josefin Nilsson, Olof Elvstam, Erik Sörstedt, Philippe Wagner, Piotr Nowak, Johanna Brännström, Christina Carlander   +6 more
wiley   +1 more source

Programming a Human Commensal Bacterium, Bacteroides thetaiotaomicron, to Sense and Respond to Stimuli in the Murine Gut Microbiota [PDF]

, 2015
Engineering commensal organisms for challenging applications, such as modulating the gut ecosystem, is hampered by the lack of genetic parts. Here, we describe promoters, ribosome-binding sites, and inducible systems for use in the commensal bacterium ...
Lu, Timothy K, Mimee, Mark K, Tucker, Alex C., Voigt, Christopher A.   +3 more
core   +1 more source

The road less taken: Dihydroflavonol 4‐reductase inactivation and delphinidin anthocyanin loss underpins a natural intraspecific flower colour variation

Molecular Ecology, EarlyView.
Abstract Visual cues are of critical importance for the attraction of animal pollinators, however, little is known about the molecular mechanisms underpinning intraspecific floral colour variation. Here, we combined comparative spectral analysis, targeted metabolite profiling, multi‐tissue transcriptomics, differential gene expression, sequence ...
Darren C. J. Wong, Zemin Wang, James Perkins, Xin Jin, Grace Emma Marsh, Emma Grace John, Rod Peakall   +6 more
wiley   +1 more source

Precision design of stable genetic circuits carried in highly‐insulated E. coli genomic landing pads

Molecular Systems Biology, 2020
Genetic circuits have many applications, from guiding living therapeutics to ordering process in a bioreactor, but to be useful they have to be genetically stable and not hinder the host. Encoding circuits in the genome reduces burden, but this decreases
Yongjin Park, Amin Espah Borujeni, Thomas E Gorochowski, Jonghyeon Shin, Christopher A Voigt   +4 more
doaj   +1 more source

Draft Genome Sequence of Mycobacterium heckeshornense Strain RLE. [PDF]

, 2015
We report here the draft genome sequence of Mycobacterium heckeshornense strain RLE isolated from a sputum sample from a patient with shortness of breath.
Chiu, Charles Y, Cunningham, Gail, Greninger, Alexander L, Miller, Steve   +3 more
core   +1 more source