Results 61 to 70 of about 13,949 (234)
Brujita Integrase: A Simple, Arm-Less, Directionless, and Promiscuous Tyrosine Integrase System [PDF]
Journal of Molecular Biology, 2016 Mycobacteriophage Brujita is an unusual temperate phage in which establishment of superinfection immunity is dependent on chromosomal integration. Integration is mediated by a non-canonical tyrosine integrase (Int) lacking an N-terminal domain typically associated with binding to arm-type sites within the phage attachment site (attP).
Bryce L. Lunt, Graham F. Hatfull
openaire +3 more sources
A Bacterial Sulfotransferase Catalyzes an Unusual Di‐Sulfation in Natural Products Biosynthesis
ChemBioChem, EarlyView.Herein, a unique sulfotransferase, AdpST, is identified from the adp biosynthetic gene clusters (BGC) in Streptomyces davaonensis DSM101723 and demonstrates that AdpST possesses di‐sulfation activity, which is unprecedented for bacterial phosphoadenosine‐5’‐phosphosulfate (PAPS)‐dependent sulfotransferases. It is further shown that the adp BGC contains
Conor Pulliam +5 more
wiley +1 more source
Mobile DNA, 2011 Background Integrons are found in hundreds of environmental bacterial species, but are mainly known as the agents responsible for the capture and spread of antibiotic-resistance determinants between Gram-negative pathogens.
Cambray Guillaume +9 more
doaj +1 more source
Attachment site selection and identity in Bxb1 serine integrase-mediated site-specific recombination. [PDF]
PLoS Genetics, 2013 Phage-encoded serine integrases mediate directionally regulated site-specific recombination between short attP and attB DNA sites without host factor requirements.
Shweta Singh +2 more
doaj +1 more source
Lamellarin D Acts as an Inhibitor of Type I Collagen Production
ChemMedChem, EarlyView.COL1A2 gene, encoding type I collagen, is a key target for pulmonary fibrosis. We established a screening system to identify small molecules that inhibit COL1A2 gene expression. Using this system, we screen a library of compounds and identify lamellarin D as a potent inhibitor of COL1A2 expression, suggesting lamellarin D is a promising new lung ...
Daisuke Okuno +19 more
wiley +1 more source
Evolution of Integrase Resistance During Failure of Integrase Inhibitor-Based Antiretroviral Therapy [PDF]
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2010 Although integrase inhibitors are highly effective in the management of drug-resistant HIV, some patients fail to achieve durable viral suppression. The long-term consequences of integrase inhibitor failure have not been well defined.We identified 29 individuals who exhibited evidence of incomplete viral suppression on a regimen containing an integrase
Wei Huang +11 more
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Silver Nanoparticle‐Mediated Antiviral Efficacy against Enveloped Viruses: A Comprehensive Review
Global Challenges, EarlyView.Silver nanoparticles (AgNPs) exhibit broad‐spectrum antiviral activity by targeting key viral structures and processes. They disrupt viral envelopes, compromising integrity, and bind to nucleocapsids, impairing viral replication. AgNPs also inhibit glycoprotein interactions, preventing viral attachment and entry into host cells.
Ekaterine Mosidze +8 more
wiley +1 more source
Filamentous phages of Ralstonia solanacearum: Double-edged swords for pathogenic bacteria
Frontiers in Microbiology, 2013 Some phages from genus Inovirus use host or bacteriophage-encoded site-specific integrases or recimbinases establish a prophage state. During integration or excision, a superinfective form can be produced.
Takashi eYamada
doaj +1 more source
Journal of Global Antimicrobial Resistance, 2020 This study evaluated the emergence of mutations associated with integrase strand transfer inhibitors (INSTI) resistance (INSTI-RMs) and the integrase evolution in human immunodeficiency virus type 1 (HIV-1) infected patients treated with this drug class.The emergence of INSTI-RMs and integrase evolution (estimated as genetic distance between integrase ...
Scutari, Rossana +14 more
openaire +9 more sources