Results 61 to 70 of about 14,447 (191)
HIV Medicine, EarlyView.Abstract Aim This study compared acute psychological responses to a single session of low‐volume high‐intensity interval exercise (HIIE‐LV), high‐volume high‐intensity interval exercise (HIIE‐HV), and moderate‐intensity continuous exercise (MICE) in people living with HIV, and healthy controls using a randomized, counterbalanced crossover design ...
Phelipe Wilde +9 more
wiley +1 more source
HIV Medicine, EarlyView.Abstract Introduction Long‐acting injectable antiretroviral therapy (ART) with Cabotegravir (CAB) and Rilpivirine (RPV) offers an alternative to daily oral regimens, improving adherence and patient satisfaction. However, its impact on body composition and metabolism remains underexplored.
Andrea De Vito +13 more
wiley +1 more source
Journal of Sleep Research, EarlyView.ABSTRACT We conducted a cross‐sectional analysis of the baseline survey of participants aged > 30 years enrolled in the Mwanza HIV&CVD Cohort in Tanzania. Our primary objective was to examine the association between HIV status and sleep apnea (SA).
Godfrey A. Kisigo +9 more
wiley +1 more source
Defense Systems and Prophage Detection in Streptococcus mutans Strains
Molecular Oral Microbiology, EarlyView.ABSTRACT Although the species is extensively studied, limited data are available on antiphage defense systems (APDSs) in Streptococcus mutans. The present study aimed to explore the diversity and the occurrence of APDSs and to search for prophages in the genomes of clinical isolates of S. mutans using bioinformatics tools.
Olivier Claisse +3 more
wiley +1 more source
Target DNA bending by the Mu transpososome promotes careful transposition and prevents its reversal
eLife, 2017 The transposition of bacteriophage Mu serves as a model system for understanding DDE transposases and integrases. All available structures of these enzymes at the end of the transposition reaction, including Mu, exhibit significant bends in the ...
James R Fuller, Phoebe A Rice
doaj +1 more source
Engineering Conditional Transgene Expression in Nicotiana benthamiana
Plant Biotechnology Journal, EarlyView.ABSTRACT Nicotiana benthamiana has emerged as a premier plant biofactory for recombinant protein and metabolite production due to its high metabolic versatility, ease of cultivation and permissiveness to transient expression vectors. However, challenges such as transgene silencing, low yields and metabolic toxicity limit its scalability. Synthetic gene
Elena Garcia‐Perez +2 more
wiley +1 more source
Diversity of FAAL enzymes and prediction of their substrate specificity using FAALPred
Protein Science, Volume 35, Issue 2, February 2026.Abstract FAALs (fatty acyl‐AMP ligases) recruit and incorporate fatty acids during the biosynthesis of secondary metabolites. Their diversity, distribution, and substrate specificity remain poorly understood, which limits functional predictions from sequence data.
Anne Liong +2 more
wiley +1 more source
Development of circular AAV cargos for targeted seamless insertion with large serine integrases
Molecular Therapy: Methods & Clinical DevelopmentRecent advancements in gene insertion have shifted from DNA-repair-dependent mechanisms to more precise approaches, enhancing safety and predictability for editing outcomes. Integrase-mediated programmable genomic integration (I-PGI) utilizes a DNA cargo
Brett J.G. Estes +12 more
doaj +1 more source
Precision design of stable genetic circuits carried in highly‐insulated E. coli genomic landing pads
Molecular Systems Biology, 2020 Genetic circuits have many applications, from guiding living therapeutics to ordering process in a bioreactor, but to be useful they have to be genetically stable and not hinder the host. Encoding circuits in the genome reduces burden, but this decreases
Yongjin Park +4 more
doaj +1 more source
Protease‐mediated maturation of M‐PMV reverse transcriptase into a functional heterodimer
Protein Science, Volume 35, Issue 2, February 2026.Abstract Reverse transcriptase (RT) of retroviruses orchestrates viral replication, yet its structural diversity remains poorly understood. Well‐studied RTs, such as those from HIV‐1, murine leukemia virus, and avian myeloblastosis virus, were characterized decades ago, but less prominent retroviruses have escaped detailed analysis.
Marina Kapisheva +6 more
wiley +1 more source