Results 111 to 120 of about 540,449 (289)

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

Advanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang, Xiaotian Yuan, Kelei Gao, Bo You, Yaxuan Wang, Lai Meng, Zirong Chen, Shaobing Xie, Yunqing Liu, Zijian Dong, Shumin Xie, Ruohao Fan, Fengjun Wang, Junyi Zhang, Zhihai Xie, Yongzhen Mo, Hua Zhang, Weihong Jiang   +17 more
wiley   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Perancangan Integrated Marketing Communication Total Buah Segar Surabaya [PDF]

, 2014
Meningkatnya konsumsi buah di Kota Surabaya menyebabkan persaingan bisnis retail buah segar semakin memanas. Berdasarkan potensi permintaan konsumsi buah yang diperoleh dari data Badan Pusat Statistik, maka Total Buah Segar membuka cabang di jl.Tunjungan
H, P. W. (Prayanto), Sukanto, D. (Denny), Yudani, H. D. (Hen)   +2 more
core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Persepsi Konsumen Terhadap Strategi Komunikasi Pemasaran Terpadu (Studi Deskriptif Kuantitatif di Pabrik Jamu Gujati 59 Kabupaten Sukoharjo) [PDF]

, 2018
Marketing communication is currently a trend among entrepreneurs to increase sales, while from the buyers sides it becomes a means of knowledge about the products sold by a company.
-, Dr. Dian Purworini, S.sos,MM, Mukti, Anggi hari   +1 more
core  

Wafer Scale III‐Nitride Deep‐Ultraviolet Vertical‐Cavity Surface‐Emitting Lasers Featuring Nanometer‐Class Control of Cavity Length

Advanced Science, EarlyView.
A DUV‐VCSEL strategy featuring the nanometer‐class control of the cavity length is proposed in the DUV optoelectronic framework based on GaN templates. After the sapphire removal, a self‐terminated etching technology is developed, whereby the cavity length can be accurately determined by epitaxy instead of the fabrication process. As such, a record low
Chen Ji, Jiaming Wang, Fujun Xu, Lisheng Zhang, Jing Lang, Ziyao Zhang, Fuyun Tan, Chengzhi Ji, Junchuan Zhang, Erfei Zhang, Xiangning Kang, Zhixin Qin, Guangxu Ju, Jiejun Wu, Xuelin Yang, Ning Tang, Xinqiang Wang, Weikun Ge, Bo Shen   +18 more
wiley   +1 more source

Practitioners’ view of the role of OOH advertising media in IMC campaigns

Management : Journal of Contemporary Management Issues, 2016
Despite the traction that contemporary out-of-home advertising has gained in the global media landscape, there are still some ambiguities regarding the contribution of this medium in the context of integrated marketing communication.
A. Therese Roux
doaj  

Upaya Komunikasi Pemasaran Interaktif pada Klinik Spesialis Terpadu Rumah Sakit Gigi dan Mulut (Rsgm) Fakultas Kedokteran Gigi Unair Surabaya [PDF]

, 2004
Integrated Marketing Communications (IMC) constitute of internal marketing, interactive and external communications. This research only addresses Interactive marketing communications.
Bachroen, C. (Cholis), Budisuari, M. A. (Made)   +1 more
core  

Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli

Advanced Science, EarlyView.
An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng, Hao Liu, Haolin Han, Meng Meng, Shaojie Wang, Tianwei Tan, Haijia Su   +6 more
wiley   +1 more source

Analysing the use of integrated marketing communication at the View Boutique Hotel in Johannesburg, South Africa [PDF]

African Journal of Hospitality, Tourism and Leisure, 2019
Integrated marketing communication (IMC) is an instrument whereby organisations can create and nurture stakeholder relationships. The aim of this study was to analyse the use of IMC by the View Boutique Hotel in Johannesburg, South Africa. To analyse the
Chinelo Ogochukwu Mebuge, Takalani Mudzanani   +1 more
doaj