Results 171 to 180 of about 10,095,518 (284)

Integrated stress response couples mitochondrial fitness with lineage reprogramming to drive cancer evolution. [PDF]

Nat Cell Biol
Diao S, Zou JY, Wang S, Chan JE, Kortlever RM, Poulain N, Ghaddar N, Kim H, Evan GI, Koumenis C, Hatzoglou M, Walter P, Sonenberg N, Le Quesne J, Tammela T, Koromilas AE.   +15 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Inhibition of the mitochondrial pyruvate carrier attenuates the integrated stress response activation in a cellular model of Huntington's disease. [PDF]

Mol Cell Biochem
Oliveira Â, Almeida LM, Oliveira JMA, Pinho BR.   +3 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Identification of biomarkers associated with integrated stress response in pituitary adenomas based on bioinformatics. [PDF]

Discov Oncol
Sui Y, Yang Z, Zhang W.
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

SIRT2 mediates integrated stress response by deacetylating and stabilizing 4E-BP1 to suppress translation. [PDF]

EMBO Rep
Zi Y, Zhao J, Wang M, Hou D, Cerione RA, Lin H.   +5 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response. [PDF]

Nat Commun
Shilliday F, Gancedo-Rodrigo M, George G, Aibara S, Adhikari S, Ashraf SN, Barrey EJ, Centrella PA, Crowther D, Dickson P, Gikunju D, Guié MA, Guilinger JP, Gunnarsson A, Harding HP, Hupp CD, Jetson R, Keefe AD, Kim JM, Lewis RJ, Maia de Oliveira T, Le-Marshall J, Narayanan U, Nugai KA, Petrović D, Rivers E, Ron D, Stringfellow D, Syson K, Ward L, Yeoman JTS, Yu Y, Zhang Y, Zyryanova A, Baker DJ, Breccia P, Linley JE.   +36 more
europepmc   +2 more sources

Ageing promotes metastasis via activation of the integrated stress response. [PDF]

Nature
Patel AAH, Dzanan JJ, Ali KX, Eklund EA, Alvarez SW, Raj D, Dankis M, Altinönder I, Schwarz M, Le Gal K, Bedel E, El Zowalaty AE, Jonasson E, Albatrok H, Gul N, Bossowski JP, Pillai R, Micke P, Botling J, Akyürek LM, Angeletti D, Sayin SI, Härtlova A, Papagiannakopoulos T, Olofsson Bagge R, Ståhlberg A, Hallqvist A, Wiel C, Sayin VI.   +28 more
europepmc   +1 more source