Results 181 to 190 of about 10,043,563 (299)

Regulated expression of multi-drug efflux transporters and their physiological roles in anaerobic adaptation in E. coli

, 2010
The 2010 Gordon Research Conference on Microbial Stress Response, South Hadley, MA., 18-23 July ...
Xiao, M, Nishino, K, Zhang, Y, Yan, A
core  

Mapping the GDF15 arm of the integrated stress response in human cells and tissues. [PDF]

Commun Biol
Smith JLM, Tanner KT, Devine J, Monzel AS, Batjargal T, Wilson MZ, Cohen AA, Picard M.   +7 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Roles of the integrated stress response in regulation of inflammatory reactions. [PDF]

Front Immunol
Jiang F, Liu GS, Liu J, Cui X, Xing Y.
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The Dysregulation of the Integrated Stress Response in Leukemic Stem Cells as a Marker of Treatment Sensitivity in Acute Myeloid Leukemia. [PDF]

Genes (Basel)
Dutti GB, Mangialardi K, Rasola S, Sebastio L, Tarantini F, Cumbo C, Anelli L, Zagaria A, Coccaro N, Minervini A, Tota G, Redavid I, Conserva MR, Musto P, Albano F.   +14 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Distinct cell type-specific mechanisms underlie cognitive dysfunction during persistent integrated stress response activation. [PDF]

Proc Natl Acad Sci U S A
Torkenczy K, Reineke LC, Dooling SW, Henderson BW, Yang B, He D, Myers RM, Walter P, Tyanova S, Costa-Mattioli M.   +9 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The integrated stress response in cancer: mechanisms of tumor adaptation and therapeutic targeting. [PDF]

Biochem Soc Trans
Maldonado E, McIsaac E, Ursini-Siegel J.
europepmc   +1 more source