Results 271 to 280 of about 10,043,563 (299)

Integrated Stress Response in Neuronal Pathology and in Health

Biochemistry (Moscow), 2022
Neurodegeneration involves progressive pathological loss of a specific population of neurons, glial activation, and dysfunction of myelinating oligodendrocytes leading to cognitive impairment and altered movement, breathing, and senses. Neuronal degeneration is a hallmark of aging, stroke, drug abuse, toxic chemical exposure, viral infection, chronic ...
openaire   +2 more sources

Mammalian integrated stress responses in stressed organelles and their functions

Acta Pharmacologica Sinica
The integrated stress response (ISR) triggered in response to various cellular stress enables mammalian cells to effectively cope with diverse stressful conditions while maintaining their normal functions. Four kinases (PERK, PKR, GCN2, and HRI) of ISR regulate ISR signaling and intracellular protein translation via mediating the phosphorylation of ...
Hao-Jun, Lu, Nirmala, Koju, Rui, Sheng
openaire   +2 more sources

Integrated stress response on the brain

Science, 2019
Structural Biology During translation, regulation of protein synthesis by phosphorylation of eukaryotic translation initiation factor 2 (eIF2) is a common consequence of diverse stress stimuli, which leads to reprogramming of gene expression.
openaire   +1 more source

Integrated Responses of Plants to Stress

BioScience, 1991
In both natural and agricultural communities, the environment is seldom optimal for plant growth. Environmental stress limits the overall productivity of US agriculture to 25% of its potential (Boyer 1982). All mesic environments experience large seasonal fluctuations in light, moisture, temperature, and nutrients, often to levels that are suboptimal ...
openaire   +1 more source

eIF3d directs the integrated stress response

Nature Cell Biology, 2023
openaire   +2 more sources

Ribosome quality control antagonizes the activation of the integrated stress response on colliding ribosomes

Molecular Cell, 2021
Liewei L Yan, Hani S Zaher
exaly  

OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy

Cell Metabolism, 2022
Patrick Giavalisco, Thomas Langer, Hendrik Nolte   +2 more
exaly  

The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2

Cell Reports, 2023
Jose Pedro Friedmann Angeli, Colin R. Goding, Svenja Meierjohann   +2 more
exaly  

The Integrated Stress Response

2022
openaire   +1 more source

The integrated stress response to the rescue of the starved heart

Cardiovascular Research, 2022
Jan Dudek, Edoardo Bertero, Christoph Maack   +2 more
openaire   +2 more sources