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The integrated stress response in ischemic diseases
Cell Death & Differentiation, 2021Ischemic disease is among the deadliest and most disabling illnesses. Prominent examples include myocardial infarction and stroke. Most, if not all, underlying pathological changes, including oxidative stress, inflammation, and nutrient deprivation, are potent inducers of the integrated stress response (ISR).
Guangyu Zhang +4 more
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eIF3d controls the persistent integrated stress response
Molecular Cell, 2023Cells respond to intrinsic and extrinsic stresses by reducing global protein synthesis and activating gene programs necessary for survival. Here, we show that the integrated stress response (ISR) is driven by the non-canonical cap-binding protein eIF3d that acts as a critical effector to control core stress response orchestrators, the translation ...
Amy Lee
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Integrating stress responses and immunity
Science, 2019Stress is required to assemble immune signaling complexes during ...
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Induction of the integrated stress response in the rat cornea
Experimental Eye Research, 2021Keratoconus (KC), a progressive, degenerative corneal disease, represents the second leading indication for corneal transplantation globally. We have previously demonstrated that components of the Integrated Stress Response (ISR) are upregulated in human keratoconic donor tissue, and treatment of normal tissue with ISR agonists attenuates collagen ...
C, Peterson +4 more
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eIF4E integrates into stress response
Molecular CellIn this issue, Diamond et al.1 and Kim et al.2 report that depletion of eIF4E leads to translational upregulation of GCN4, a key player in the integrated stress response, in an eIF2α phosphorylation-independent manner, suggesting a new mode of translational adaptation.
Xincheng, Wu, Shu-Bing, Qian
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Integrating the response to stressed mitochondria
Molecular CellChakrabarty et al.1 demonstrate that phospho-EIF2α (pEIF2α), the translation initiation factor that mediates the integrated stress response (ISR), is necessary and sufficient for the autophagic degradation of mitochondria following the addition of mitochondrial stressors.
Elliot, Dine, Richard J, Youle
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The Unfolded Protein Response and Integrated Stress Response to Anoxia
Clinical Cancer Research, 2007Abstract The lack of oxygen delivery to tumor cells has profound consequences for tumor growth and correlates with poor prognosis. Some tumors contain regions of very severe hypoxia called anoxia, which constitutes a functionally different state to hypoxia. In response to anoxia, mammalian cells induce coordinated cytoprotective programs
Tomasz, Rzymski, Adrian L, Harris
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Integrated Stress Response in Neuronal Pathology and in Health
Biochemistry (Moscow), 2022Neurodegeneration involves progressive pathological loss of a specific population of neurons, glial activation, and dysfunction of myelinating oligodendrocytes leading to cognitive impairment and altered movement, breathing, and senses. Neuronal degeneration is a hallmark of aging, stroke, drug abuse, toxic chemical exposure, viral infection, chronic ...
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Mammalian integrated stress responses in stressed organelles and their functions
Acta Pharmacologica SinicaThe integrated stress response (ISR) triggered in response to various cellular stress enables mammalian cells to effectively cope with diverse stressful conditions while maintaining their normal functions. Four kinases (PERK, PKR, GCN2, and HRI) of ISR regulate ISR signaling and intracellular protein translation via mediating the phosphorylation of ...
Hao-Jun, Lu, Nirmala, Koju, Rui, Sheng
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Integrated stress response on the brain
Science, 2019Structural Biology During translation, regulation of protein synthesis by phosphorylation of eukaryotic translation initiation factor 2 (eIF2) is a common consequence of diverse stress stimuli, which leads to reprogramming of gene expression.
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