Results 251 to 260 of about 10,043,563 (299)

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Cannabidiol Activates Integrated Stress Response Signaling and Immune Trafficking Programs in an A375 Melanoma-Jurkat T Cell Coculture Model: A Multi-Omics Analysis. [PDF]

ACS Omega
Deng N, Li H, Cai A, Hemme CL, Youn J, Janis R, Stone MD, Ma H, Liu C.   +8 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response. [PDF]

Nat Commun
Tjeerdsma RB, Ng TF, Roorda M, Bianchi D, Yang S, Bonnet C, VanInsberghe M, Everts M, Bakker FJ, de Boer HR, Moatti N, Hustedt N, Yin JZ, Hoeg L, Leibovitch M, Sicheri F, van Oudenaarden A, de Jong S, van den Berg J, Tanenbaum ME, Brummelkamp TR, Durocher D, van Vugt MATM.   +22 more
europepmc   +1 more source

The G3BP stress-granule proteins reinforce the integrated stress response translation programme. [PDF]

Nat Cell Biol
Smith J, Bartel DP.
europepmc   +1 more source

The Yin-Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease. [PDF]

Biocell
Ruden DM.
europepmc   +1 more source

Integrated Stress Response and Drug-Induced Acute Kidney Injury: Involvement of Activating ATF4-STAT1-GBP2 Signaling. [PDF]

J Am Soc Nephrol
Zhang H, Sun X, Shen Y, Li Y, Nie Z, Chen Z, Kong Y, Chen Z, Liu X, Gui D, Chen W.   +10 more
europepmc   +1 more source

Integrated stress response genes as novel biomarkers and therapeutic targets in ankylosing spondylitis: a transcriptomic and Mendelian randomization study. [PDF]

Front Immunol
Wang S, Zhu J, Zhang H, Hu S, Mei J, Zhou C, Shi B.   +6 more
europepmc   +1 more source

RAF inhibitors activate the integrated stress response by direct activation of GCN2. [PDF]

Nat Commun
Gilley R, Kidger AM, Neill G, Morrison E, Severson P, Byrne DP, Kenneth NS, Bollag G, Zhang C, Maia de Oliveira T, Eyers PA, Bayliss R, Masson GR, Cook SJ.   +13 more
europepmc   +1 more source