Results 241 to 250 of about 10,095,518 (284)

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

CDC123 is an ATPase that modulates mRNA translation and the integrated stress response by regulating eIF2 complex assembly. [PDF]

J Biol Chem
Erb AL, Young-Baird SK.
europepmc   +1 more source

Emerging roles for integrated stress response signaling in homeostasis. [PDF]

FEBS J
Nandakumar S, Grmai L, Vasudevan D.
europepmc   +1 more source

SARS-CoV-2 and MERS-CoV disrupt host protein synthesis via nsp1 with differential effects on the integrated stress response. [PDF]

Proc Natl Acad Sci U S A
Parenti NA, Cusic R, Renner DM, Jackson N, Ye C, Tan LH, Pfannenstiel JJ, Fehr AR, Cohen NA, Martinez-Sobrido L, Burke JM, Weiss SR.   +11 more
europepmc   +1 more source

Inhibition of the integrated stress response rescues a histidyl-tRNA synthetase variant associated with Charcot-Marie-Tooth disease. [PDF]

NAR Mol Med
Mahmood M, Wilhelm SDP, Mendes MI, Smith DE, Kenana R, Hoffman K, Moresco AA, Siu VM, Heinemann IU.   +8 more
europepmc   +1 more source

Pharmacological targeting of RIG-I can selectively activate the integrated stress response. [PDF]

Sci Adv
Cuoco CA, Ren W, Baron KR, Gologo S, Perea V, Mathur P, Bora P, Ta A, Chu A, Aldakhlallah R, Rhoades D, Cole CM, Tan EP, Hou WC, Yoon L, Guo X, Rosarda JD, Baran PS, Kampmann M, Tillery L, Johnson KA, Powers ET, Wiseman RL, Kelly JW.   +23 more
europepmc   +1 more source

The integrated stress response [PDF]

EMBO Reports, 2016
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis.
Izabela Koryga, Adrienne Gorman, A Samali   +2 more
exaly   +6 more sources

The Integrated Stress Response in Lung Disease [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2014
Lungs are repeatedly exposed to inhaled toxic insults, such as smoke, diesel exhaust, and microbes, which elicit cellular stress responses. The phosphorylation of eukaryotic translation initiation factor 2α by one of four stress-sensing kinases triggers ...
Stefan Marciniak, Pieter Hiemstra
exaly   +7 more sources

Folding the Mitochondrial UPR into the Integrated Stress Response

Trends in Cell Biology, 2020
Eukaryotic cells must accurately monitor the integrity of the mitochondrial network to overcome environmental insults and respond to physiological cues. The mitochondrial unfolded protein response (UPRmt) is a mitochondrial-to-nuclear signaling pathway that maintains mitochondrial proteostasis, mediates signaling between tissues, and regulates ...
Cole Haynes
exaly   +4 more sources

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Surviving and Adapting to Stress: Translational Control and the Integrated Stress Response

Antioxidants and Redox Signaling, 2023
Significance: Organisms adapt to changing environments by engaging cellular stress response pathways that serve to restore proteostasis and enhance survival. A primary adaptive mechanism is the integrated stress response (ISR), which features phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2).
Kirk Staschke, Ronald Wek, Tracy G Anthony   +2 more
exaly   +3 more sources