Results 221 to 230 of about 466,137 (253)

Surviving and Adapting to Stress: Translational Control and the Integrated Stress Response

Antioxidants & Redox Signaling, 2023
Significance: Organisms adapt to changing environments by engaging cellular stress response pathways that serve to restore proteostasis and enhance survival. A primary adaptive mechanism is the integrated stress response (ISR), which features phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2).
Ronald C. Wek, Tracy G. Anthony, Kirk A. Staschke   +2 more
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eIF4E integrates into stress response

Molecular Cell
In this issue, Diamond et al.1 and Kim et al.2 report that depletion of eIF4E leads to translational upregulation of GCN4, a key player in the integrated stress response, in an eIF2α phosphorylation-independent manner, suggesting a new mode of translational adaptation.
Xincheng, Wu, Shu-Bing, Qian
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Integrating stress responses and immunity

Science, 2019
Stress is required to assemble immune signaling complexes during ...
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Induction of the integrated stress response in the rat cornea

Experimental Eye Research, 2021
Keratoconus (KC), a progressive, degenerative corneal disease, represents the second leading indication for corneal transplantation globally. We have previously demonstrated that components of the Integrated Stress Response (ISR) are upregulated in human keratoconic donor tissue, and treatment of normal tissue with ISR agonists attenuates collagen ...
C, Peterson, Y C, Kim, L M, Ensign, A S, Jun, J, Foster   +4 more
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The Unfolded Protein Response and Integrated Stress Response to Anoxia

Clinical Cancer Research, 2007
Abstract The lack of oxygen delivery to tumor cells has profound consequences for tumor growth and correlates with poor prognosis. Some tumors contain regions of very severe hypoxia called anoxia, which constitutes a functionally different state to hypoxia. In response to anoxia, mammalian cells induce coordinated cytoprotective programs
Tomasz, Rzymski, Adrian L, Harris
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Integrating the response to stressed mitochondria

Molecular Cell
Chakrabarty et al.1 demonstrate that phospho-EIF2α (pEIF2α), the translation initiation factor that mediates the integrated stress response (ISR), is necessary and sufficient for the autophagic degradation of mitochondria following the addition of mitochondrial stressors.
Elliot, Dine, Richard J, Youle
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Mammalian integrated stress responses in stressed organelles and their functions

Acta Pharmacologica Sinica
The integrated stress response (ISR) triggered in response to various cellular stress enables mammalian cells to effectively cope with diverse stressful conditions while maintaining their normal functions. Four kinases (PERK, PKR, GCN2, and HRI) of ISR regulate ISR signaling and intracellular protein translation via mediating the phosphorylation of ...
Hao-Jun, Lu, Nirmala, Koju, Rui, Sheng
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Integrated Stress Response in Neuronal Pathology and in Health

Biochemistry (Moscow), 2022
Neurodegeneration involves progressive pathological loss of a specific population of neurons, glial activation, and dysfunction of myelinating oligodendrocytes leading to cognitive impairment and altered movement, breathing, and senses. Neuronal degeneration is a hallmark of aging, stroke, drug abuse, toxic chemical exposure, viral infection, chronic ...
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Integrated Responses of Plants to Stress

BioScience, 1991
In both natural and agricultural communities, the environment is seldom optimal for plant growth. Environmental stress limits the overall productivity of US agriculture to 25% of its potential (Boyer 1982). All mesic environments experience large seasonal fluctuations in light, moisture, temperature, and nutrients, often to levels that are suboptimal ...
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Integrated stress response on the brain

Science, 2019
Structural Biology During translation, regulation of protein synthesis by phosphorylation of eukaryotic translation initiation factor 2 (eIF2) is a common consequence of diverse stress stimuli, which leads to reprogramming of gene expression.
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