Results 211 to 220 of about 466,137 (253)

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes. [PDF]

Cell Commun Signal
Wang JE, Muralidharan C, Puente AA, Nargis T, Enriquez JR, Anderson RM, Mirmira RG, Tersey SA.   +7 more
europepmc   +1 more source

Prime editing links the split integrated stress response to pathogenic eIF2B mutations and white matter degeneration. [PDF]

Cell Death Dis
Scagliola A, Miluzio A, Pauselli M, Ceci M, Biffo S, Ricciardi S.   +5 more
europepmc   +1 more source

Cytosolic Immunostimulatory DNA Ligands and DNA Damage Activate the Integrated Stress Response, Stress Granule Formation, and Cytokine Production. [PDF]

Cells
Devale T, Katuri L, Mishra G, Acharya A, Manivannan P, Hibbard BR, Malathi K.   +6 more
europepmc   +1 more source

Convergent activation of the integrated stress response and ER-mitochondria uncoupling in VAPB-associated ALS. [PDF]

EMBO Mol Med
Landry C, Costanzo JP, Mitne-Neto M, Zatz M, Schaffer AE, Hatzoglou M, Muotri AR, Miranda HC.   +7 more
europepmc   +1 more source

A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response

Shilliday F, Gancedo-Rodrigo M, George G, Adhikari S, Ashraf SN, Barrey EJC, Centrella PA, Crowther D, Dickson P, Gikunju D, Guié M, Guilinger JP, Gunnarsson A, Harding HP, Hupp CD, Jetson R, Keefe AD, Kim JM, Lewis RJ, de Oliveira TM, Le-Marshall J, Narayanan U, Nugai KA, Petrović D, Rivers E, Ron D, Stringfellow D, Syson K, Ward L, Yeoman JTS, Yu Y, Zhang Y, Zyryanova A, Baker D, Breccia P, Linley J.   +35 more
europepmc   +1 more source

The integrated stress response [PDF]

EMBO Reports, 2016
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2¿) by one of four members of the eIF2¿ kinase family, which leads to a ...
Izabela Koryga, Katarzyna Mnich, Mila Ljujić   +2 more
exaly   +5 more sources

Folding the Mitochondrial UPR into the Integrated Stress Response

Trends in Cell Biology, 2020
Eukaryotic cells must accurately monitor the integrity of the mitochondrial network to overcome environmental insults and respond to physiological cues. The mitochondrial unfolded protein response (UPRmt) is a mitochondrial-to-nuclear signaling pathway that maintains mitochondrial proteostasis, mediates signaling between tissues, and regulates ...
Cole M Haynes
exaly   +4 more sources

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eIF3d controls the persistent integrated stress response

Molecular Cell, 2023
Cells respond to intrinsic and extrinsic stresses by reducing global protein synthesis and activating gene programs necessary for survival. Here, we show that the integrated stress response (ISR) is driven by the non-canonical cap-binding protein eIF3d that acts as a critical effector to control core stress response orchestrators, the translation ...
Amy S Y Lee
exaly   +3 more sources

The integrated stress response in ischemic diseases

Cell Death & Differentiation, 2021
Ischemic disease is among the deadliest and most disabling illnesses. Prominent examples include myocardial infarction and stroke. Most, if not all, underlying pathological changes, including oxidative stress, inflammation, and nutrient deprivation, are potent inducers of the integrated stress response (ISR).
Guangyu Zhang, Xiaoding Wang, Beverly A. Rothermel, Sergio Lavandero, Zhao V. Wang   +4 more
openaire   +2 more sources