Results 91 to 100 of about 3,646,059 (297)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Analysis of Threaded-Type Integrated Learning Model in Developing Creativity and Critical Thinking

Pena Anda
Teaching and learning activities in elementary schools prioritize mastery of material or theory-based. This research aims to evaluate the effectiveness of the Threaded-type integrated learning model in developing the creative thinking skills of ...
Zaza Bella Ummi Rahmah, Ratu Bulkis Kamaliyah   +1 more
doaj   +1 more source

EARTH Integrated Archaeology Rapporten 166

, 2022
EARTH Integrated Archaeology B.V. heeft in november 2020 - februari 2021 een Inventariserend Veldonderzoek (IVO) waarderende fase door middel van boringen uitgevoerd in plangebied Goudplevierweg-Kathedralenpad in Oosterwold, gemeente Almere.
Rumping, BSc S. (EARTH Integrated Archaeology), Devriendt, Dr. I., Moor, Dr. J.J.W. de (EARTH Integrated Archaeology)   +2 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Critical Thinking and Challenges for Education for Democratic Citizenship: an ethnographic study in primary schools in Greece

Educação & Realidade, 2018
This paper reports on an ethnographic multiple case study in Greece. It explores teachers’ practices regarding the education of critically thinking citizens ten years into the implementation of an integrated curriculum reform.
Ioanna Noula
doaj   +3 more sources

Effectiveness of Integrated Interactive Problem Based Learning E-Modules in Improving Critical Thinking Abilities

Jurnal Paedagogy
This study aims to analyze the improvement of students' critical thinking skills by using interactive modules integrated with problem-based learning on the excretory system material.
Afreni Hamidah, Hawalya Hawalya, M. Erick Sanjaya   +2 more
doaj   +1 more source

EARTH Integrated Archaeology Rapporten 136

, 2022
EARTH Integrated Archaeology B.V. heeft in januari 2020 een Inventariserend Veldonderzoek (IVO) verkennende fase door middel van boringen uitgevoerd in plangebied Goudplevierweg- Kathedralenpad in Oosterwold (gemeente Almere).
Rumping, BSc S (EARTH Integrated Archaeology), Moor, Dr. J.J.W. de (EARTH Integrated Archaeology)   +1 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source