Results 101 to 110 of about 2,401,515 (298)

Introducing a New Journal: BIO Integration

BIO Integration, 2020
Zhiyi Chen, Pintong Huang
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Integrative psychotherapy.

Psychiatria Danubina, 2008
The main purposes of the article are to present the history of integration in psychotherapy, the reasons of the development integrative approaches, and the approaches to integration in psychotherapy. Three approaches to integration in psychotherapy exist: theoretical integration, theoretical eclecticism, and common factors in different ...
openaire   +4 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

A Practical Bearing Failure Detection Method Using a New Efficient Deep Network With the Knowledge Self-Adaptive Evolution

Shock and Vibration
Intelligent fault diagnosis technology based on the deep neural network has shown significant advancements in recent years. However, it is difficult and expensive to deploy a fault diagnosis neural network with a huge number of parameters to an embedded ...
Mengyu Ji, Lijun Chen, Yeming Yao, Xiaoping Wang, Cheng Chang, Yunan Zhou   +5 more
doaj   +1 more source

Brazil’s Bolsa Família conditional cash transfer and child malnutrition: a nationwide birth cohort study

BMJ Global Health
Introduction Poverty amplifies the risk of malnutrition, which is particularly harmful to children as it can perpetuate a cycle of poverty and poor health.
Maurício Lima Barreto, Julia M Pescarini, Rosemeire L Fiaccone, Rita de Cássia Ribeiro-Silva, Ila R Falcão, Thiago Cerqueira-Silva, Maria Y Ichihara, Natanael J Silva, João Guilherme G Tedde, Enny Paixao, Aline dos Santos Rocha, Juliana Freitas de Mello e Silva   +11 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Extraction of Inherent Amplitude Mode from a Light Beam

Advanced Photonics Research
Mode extraction is the inverse process of the double‐beam superposition principle in classical optics. While polarization mode extraction has been successfully demonstrated using an m‐order vector vortex beam, amplitude mode extraction remains a ...
Zhiyang Xia, Xiaoyu Weng, Liwei Liu, Jun He, Changrui Liao, Yiping Wang, Junle Qu   +6 more
doaj   +1 more source

A bidirectional lightwave transport system based on PON integration with WDM VLC

, 2013
Chia-Yi Chen, Po-Yi Wu, Hai‐Han Lu, Ying-Pyng Lin, Ching-Hung Chang, Huang‐Chang Lin   +5 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source