Results 71 to 80 of about 2,401,515 (298)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Frequency transfer and inverse design for metasurface under multi-physics coupling by Euler latent dynamic and data-analytical regularizations

Nature Communications
Frequency transfer is a key challenge in machine learning as it allows researchers to go beyond in-range analyses of spectrum properties towards out-of-the-range predictions. Traditionally, to predict properties at a specific frequency, targeted spectrum
Enze Zhu, Zheng Zong, Erji Li, Yang Lu, Jingwei Zhang, Hao Xie, Ying Li, Wen-Yan Yin, Zhun Wei   +8 more
doaj   +1 more source

Monolithically Integrated Multiwavelength Laser With Optical Feedback: Damped Relaxation Oscillation Dynamics and Narrowed Linewidth

IEEE Photonics Journal, 2018
An InP-based, monolithically integrated multiwavelength laser with optical feedback is presented. We demonstrate the performance of the dual-wavelength operation. Single-mode lasing is obtained for each of the two channels within a temperature range from
Dan Zhao, Stefanos Andreou, Weiming Yao, Daan Lenstra, Kevin Williams, Xaveer Leijtens   +5 more
doaj   +1 more source

AI Business Model: An Integrative Business Approach [PDF]

, 2020
Shrutika Mishra, AR Tripathi
openalex   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Electrical Effect of Nitrogen Implanted Into LDD of MOSFETs

IEEE Journal of the Electron Devices Society
The motivation of this study was to solve the high $\rm I_{D,off}$ problem in 8 Volt N-channel MOSFET. We experimented with implanting nitrogen into LDD at various doses.
Yoo Seon Song, Markus Lenski, Mohammed F. Karim, Keith Flynn, Jan Hoentschel, Carsten Peters, Jens-Uwe Sachse, Omur Isil Aydin, Jun Wu, Bastian Hausdorfer, Mahesh Siddabathula, Konrad Semmler, Jurgen Daleiden   +12 more
doaj   +1 more source

Adaptive Integration and Improper Integrals [PDF]

Mathematics of Computation, 1975
Let R be the class of all functions that are properly Riemann-integrable on [0, 1], and let IR be the class of all functions that are properly Riemann-integrable on [a, 1] for all a > 0 a > 0 and for which \[ lim a →
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Influence of external environment on thermal environment of cabin and optimization of air supply strategy of air conditioner

Results in Engineering
This paper employs CFD software to establish a mathematical model of a full-vehicle environmental wind tunnel, and couples it with the Berkeley thermal comfort evaluation model to assess human thermal comfort. The study investigates the impact of varying
Yingchao Zhang, Ruizhuo Zhou, Guohua Wang, Jincheng Xu, Zhe Zhang   +4 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source