Results 121 to 130 of about 86,429 (265)

Profiling of Integrin Isoforms on Lung‐Tropic Exosomes by Spectrally and Kinetically Multiplexed Single‐Molecule Imaging

Advanced Science, EarlyView.
A spectrally and kinetically multiplexed single‐molecule imaging method is developed, which achieved simultaneous imaging of 12 exosomal proteins at an unparalleled single‐copy resolution. It is found that co‐occurrence of α6 integrin and the pairing β counterpart on single exosomes is essential for lung targeting, providing valuable information for ...
Songlin Liu, Haixin Wang, Qin Shentu, Liang Yuan, Jiangshan Tie, Li Li, Rui Ai, Bochen Ma, Lubin Qi, Yifei Jiang, Xiaohong Fang   +10 more
wiley   +1 more source

β-1,4-Galactosyltransferase III Enhances Invasive Phenotypes Via β1-Integrin and Predicts Poor Prognosis in Neuroblastoma [PDF]

, 2013
Hsiu‐Hao Chang, Chia‐Hua Chen, Chih-Hsing Chou, Yung‐Feng Liao, Miao-Juei Huang, Ya-Hsin Chen, Wei-Jen Wang, John Huang, Ji‐Shiang Hung, Wan‐Ling Ho, Yung‐Ming Jeng, Mei‐Ieng Che, Hsinyu Lee, Meng‐Yao Lu, Yung‐Li Yang, Shiann‐Tarng Jou, Dong‐Tsamn Lin, Kai‐Hsin Lin, Wen‐Ming Hsu, Min‐Chuan Huang   +19 more
openalex   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

The Glycosphingolipid, Lactosylceramide, Regulates β1-Integrin Clustering and Endocytosis [PDF]

, 2005
Deepak Sharma, Jennifer C. Brown, Zhi-jie Jey Cheng, Eileen L. Holicky, David L. Marks, Richard E. Pagano   +5 more
openalex   +1 more source

Supplementary Materials and Methods from Erlotinib Resistance in Lung Cancer Cells Mediated by Integrin β1/Src/Akt-Driven Bypass Signaling

, 2023
Rina Kanda, Akihiko Kawahara, Kosuke Watari, Yûichi Murakami, Kahori Sonoda, Masashi Maeda, Hideaki Fujita, Masayoshi Kage, Hidetaka Uramoto, Carlota Costa, Michihiko Kuwano, Mayumi Ono   +11 more
openalex   +1 more source

Early Radial Extracorporeal Shockwave Stimulation on Proximal Tibial Circular Osteotomy Site Enhanced Heterotopic Skin Wound Healing via Small Extracellular Vesicles

Advanced Science, EarlyView.
A schematic diagram of the mechanism where small extracellular vesicles mediate the enhancement of heterotopic wound healing by radial extracorporeal shockwave stimulation at a proximal tibial osteotomy site. ABSTRACT Wound healing represents a complex biological process necessitating innovative therapeutic approaches, particularly for chronic wounds ...
Xiaoping Xie, Songqi Bi, Bang Su, Rongqi Zhou, Xudong Li, Zhixing Yan, Xiaoyang Zhou, Fanxu Wang, Tiecheng Yu   +8 more
wiley   +1 more source

Micro‐Organ Chip Deciphers Tumor‐Derived G‐CSF as Remote Commander of Lung Pre‐Metastatic Niche via VEGFA‐KDR Cascade

Advanced Science, EarlyView.
Breast cancer reprograms the lung into a receptive pre‐metastatic niche via a novel G‐CSF–VEGFA–KDR signaling axis. Using a micro‐organ chip that enables contact‐independent coculture, this study uncovers how tumor‐secreted G‐CSF activates lung capillary KDR to drive angiogenesis and prime the soil for metastasis—without direct tumor contact.
Jingxin Zhang, Xiaoying Huang, Lingchuan Ma, Zixing Chen, Tianyao Li, Lijian Wang, Yutong Guo, Hu Xu, Junqi Li, Jiang‐Jiang Qin, Xiang Wang, Yuhong Cao, Kai Miao   +12 more
wiley   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Supplementary Figure Legend from The Pivotal Role of Integrin β1 in Metastasis of Head and Neck Squamous Cell Carcinoma

, 2023
Dongsheng Wang, Susan J. Muller, A.R.M. Ruhul Amin, Donghai Huang, Ling Su, Zhongliang Hu, Mohammad Aminur Rahman, Sreenivas Nannapaneni, Lydia Koenig, Zhengjia Chen, Mourad Tighiouart, Dong M. Shin, Zhuo G. Chen   +12 more
openalex   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source