Results 101 to 110 of about 56,023 (262)

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

MicroRNA- 130b suppresses migration and invasion of colorectal cancer cells through downregulation of integrin β1 [corrected].

PLoS ONE, 2014
MicroRNA 130b (miR-130b) is significantly dysregulated in various human tumor types. In this study, using a microarray assay, we characterized the upregulation of miR-130b expression in colorectal cancer (CRC) specimens.
Yanyang Zhao, Gang Miao, Yao Li, Tomoya Isaji, Jianguo Gu, Jian Li, Ruomei Qi   +6 more
doaj   +1 more source

BMPR2-deficient ECs show increased activation of β1-integrin-ILK mechano-complexes, re-localization of these complexes to cell junctions, and junctional stiffening.

, 2019
(A) Immunoblot showing total β1-integrin (tITGB1) levels and phosphorylation at Ser785 and Threonine 783 (left) under steady-state conditions and densitometric quantification of total or phosphorylated β1-integrin levels in indicated cell clones (right).
Jerome Jatzlau (8115377), Kerstin G. Blank (1417786), Branka Kampfrath (8115383), Jose Luis Cuellar Camacho (8115386), Christian Hiepen (1354257), Gerhard Sengle (189245), Melis Goktas (1620901), Rainer Haag (1385424), Arunima Murgai (5233451), Susanne Hildebrandt (8115380), Clemens Ruppert (33937), Petra Knaus (202306), Elisabetta Ada Cavalcanti-Adam (791995)   +12 more
core   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Interactions between the discoidin domain receptor 1 and β1 integrin regulate attachment to collagen

Biology Open, 2013
Summary Collagen degradation by phagocytosis is essential for physiological collagen turnover and connective tissue homeostasis. The rate limiting step of phagocytosis is the binding of specific adhesion receptors, which include the integrins and ...
Lisa A. Staudinger, Stephen J. Spano, Wilson Lee, Nuno Coelho, Dhaarmini Rajshankar, Michelle P. Bendeck, Tara Moriarty, Christopher A. McCulloch   +7 more
doaj   +1 more source

Expression of β1 integrin in laminin-adhesion-selected human colon cancer cell lines of varying tumorigenicity

, 1994
Laminin has been shown to promote the malignant phenotype and the expression of certain laminin receptors has been correlated with the malignant character of the tumors. Here new cell lines were isolated from a human colon cancer cell line (LCC-C1) based
Thompson, Erik W., Kleinman, H. K., Jun, S. H., Kibbey, M. C., Kim, W. H.   +4 more
core  

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Expression of Integrins and Extracellular Matrix Proteins in Non-small Cell Lung Cancer:Correlation with Tumor Metastasis and Prognosis

Chinese Journal of Lung Cancer, 2009
Background and objective As invasion and metastasis of cancer seriously threaten human's life, it is of more important clinical significance to understand and evaluate the biologic behavior of cancer correctly.
Zhidong LIU, Haiqing ZHANG, Shaofa XU, Zhi YANG, Yi HAN   +4 more
doaj