Results 101 to 110 of about 145,582 (257)

Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling

The Journal of Clinical Investigation
The blood and lymphatic vascular systems are regulated by angiopoietin (ANGPT) growth factors, which signal via endothelial TIE receptor tyrosine kinases and integrins. However, mechanistic understanding of how these receptors crosstalk is limited. Here,
Tuomas Sipilä, Srinivas Kumar Ponna, Abhinandan Venkatesha Murthy, Anne Pink, Giray Enkavi, Shraman Kumar Bohra, Klaudia Lewna, Keerthana Ganesh, Qina Liu, Mirka Korhonen, Tommi Kajander, Michael Potente, Johanna Ivaska, Ilpo Vattulainen, Veli-Matti Leppänen, Pipsa Saharinen   +15 more
doaj   +1 more source

Expression of β1 integrin in laminin-adhesion-selected human colon cancer cell lines of varying tumorigenicity

, 1994
Laminin has been shown to promote the malignant phenotype and the expression of certain laminin receptors has been correlated with the malignant character of the tumors. Here new cell lines were isolated from a human colon cancer cell line (LCC-C1) based
Thompson, Erik W., Kleinman, H. K., Jun, S. H., Kibbey, M. C., Kim, W. H.   +4 more
core  

Treatment with A-769662 reduces cell surface β1-integrin levels.

, 2015
(A) RPE cells were stimulated with 100 μM A-769662 for 90 min or left unstimulated (basal). Intact cells were labeled with an antibody specific for an exofacial epitope on β1-integrin.
Rehman Ata (744693), Sergei Medvedev (744695), Thanusi Thavarajah (744694), Costin N. Antonescu (744698), John G. Marshall (744697), Eden Ross (744692), Peter Bowden (744696)   +6 more
core   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Interactions between the discoidin domain receptor 1 and β1 integrin regulate attachment to collagen

Biology Open, 2013
Summary Collagen degradation by phagocytosis is essential for physiological collagen turnover and connective tissue homeostasis. The rate limiting step of phagocytosis is the binding of specific adhesion receptors, which include the integrins and ...
Lisa A. Staudinger, Stephen J. Spano, Wilson Lee, Nuno Coelho, Dhaarmini Rajshankar, Michelle P. Bendeck, Tara Moriarty, Christopher A. McCulloch   +7 more
doaj   +1 more source

Integrin-α2 colocalizes with K14 in leader cells.

(A) Representative immunofluorescent images of tumor organoids with integrin-α2 (red), K14 (green) and nuclei (blue). (B) Pearson’s R value from colocalization analysis of integrin-α2 and K1. n = 23 organoids from three mice. Data shown as mean ± SEM. (C)
Anna D. Young (17720435), Corinne E. Leonard (17720441), Swadesh K. Das (12288605), Christopher A. Lemmon (9960419), Paul B. Fisher (152591), Priscilla Y. Hwang (14938194), Trey P. Redman (17720438), Ella Ramamurthy (17720432), Jessanne Y. Lichtenberg (17720429)   +8 more
core   +1 more source

BMPR2-deficient ECs show increased activation of β1-integrin-ILK mechano-complexes, re-localization of these complexes to cell junctions, and junctional stiffening.

, 2019
(A) Immunoblot showing total β1-integrin (tITGB1) levels and phosphorylation at Ser785 and Threonine 783 (left) under steady-state conditions and densitometric quantification of total or phosphorylated β1-integrin levels in indicated cell clones (right).
Jerome Jatzlau (8115377), Kerstin G. Blank (1417786), Branka Kampfrath (8115383), Jose Luis Cuellar Camacho (8115386), Christian Hiepen (1354257), Gerhard Sengle (189245), Melis Goktas (1620901), Rainer Haag (1385424), Arunima Murgai (5233451), Susanne Hildebrandt (8115380), Clemens Ruppert (33937), Petra Knaus (202306), Elisabetta Ada Cavalcanti-Adam (791995)   +12 more
core   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Expression of Integrins and Extracellular Matrix Proteins in Non-small Cell Lung Cancer:Correlation with Tumor Metastasis and Prognosis

Chinese Journal of Lung Cancer, 2009
Background and objective As invasion and metastasis of cancer seriously threaten human's life, it is of more important clinical significance to understand and evaluate the biologic behavior of cancer correctly.
Zhidong LIU, Haiqing ZHANG, Shaofa XU, Zhi YANG, Yi HAN   +4 more
doaj  

Histopathological alterations in airways associated with physiological changes in airway allergy phenotypes

Frontiers in Allergy
IntroductionOvalbumin sensitization in guinea pigs induces diverse allergic responses. The asthma model exhibits airway obstruction, hyperresponsiveness, fibrosis, and reduced airway caliber, associated with elevated β1 integrin subunit expression.
Marisol Alvarez-González, Angélica Flores-Flores, Angélica Flores-Flores, Ivonne Pacheco-Alba, Blanca Bazán-Perkins, Blanca Bazán-Perkins   +5 more
doaj   +1 more source