Results 91 to 100 of about 56,023 (262)

Beta 1 integrin predicts survival in breast cancer: a clinicopathological and immunohistochemical study

Diagnostic Pathology, 2012
Background The main focus of several studies concerned with cancer progression and metastasis is to analyze the mechanisms that allow cancer cells to interact and quickly adapt with their environment.
dos Santos Petra, Zanetti Juliana S, Ribeiro-Silva Alfredo, Beltrão Eduardo IC   +3 more
doaj   +1 more source

Protein Kinase D1 and the β1 Integrin Cytoplasmic Domain Control β1 Integrin Function via Regulation of Rap1 Activation

, 2005
SummaryThe functional activity of integrins is dynamically regulated by T cell receptor stimulation and by protein kinase C (PKC). We report a novel function for the PKC effector protein kinase D1 (PKD1) in integrin activation.
Billadeau, Daniel D., Shimizu, Yoji, Medeiros, Ricardo B., Dickey, Deborah M., Quale, Angie C., Chung, Heekyoung, Nagarajan, Lakshmi R.   +6 more
core   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Confocal laser scanning micrographs show the double-fluorescence of integrin β1-FAK (A–I), and integrin β1-WT1 (J–R).

, 2014
Under normotensive condition, integrin β1 showed intense staining along the GBM of the glomeruli (A, arrows). FAK was distributed in the cytoplasm and nuclei of the podocytes evenly (B, arrows).
Juan Wang (115708), Zilong Li (245221), Xiaoli Yuan (359671), Xiaohui Yin (547490), Xiaoyue Zhai (547491), Lining Wang (547492), Wei Wang (17594), Kai Li (205203)   +7 more
core   +1 more source

ECM‐Stiffness Mediated Persistent Fibroblast Activation Requires Integrin and Formin Dependent Chromatin Remodeling

Advanced Science, EarlyView.
Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy, Oscar André, Zhimeng Fan, Pontus Nordenfelt, Vinay S Swaminathan   +4 more
wiley   +1 more source

TIMP1 protects against blood-brain barrier disruption after subarachnoid haemorrhage by inhibiting ubiquitination of astrocytic β1-integrin

Stroke and Vascular Neurology
Background Astrocytes regulate blood-brain barrier (BBB) integrity, whereas subarachnoid haemorrhage (SAH) results in astrocyte dysregulation and BBB disruption. Here, we explored the involvement of tissue inhibitor of matrix metalloprotease-1 (TIMP1) in
Jing Liu, Huaijun Chen, Gao Chen, Hang Zhou, Cong Qian, Tianchi Tang, Linfeng Fan, Libin Hu, Jingya Ye, Chaohui Jing, Chaoran Xu, Xinyan Wu, Yike Chen, Zihang Chen, Xiongjie Fu, Jingsen Chen, Zhongju Tan, Hanhai Zeng, Fuyi Liu   +18 more
doaj   +1 more source

Upregulation of α3β1-Integrin in Podocytes in Early-Stage Diabetic Nephropathy

Journal of Diabetes Research, 2016
Background. Podocyte injury plays an important role in the onset and progression of diabetic nephropathy (DN). Downregulation of α3β1-integrin expression in podocytes is thought to be associated with podocyte detachment from the glomerular basement ...
Kaichiro Sawada, Masao Toyoda, Noriko Kaneyama, Sawako Shiraiwa, Hitomi Moriya, Han Miyatake, Eitaro Tanaka, Naoyuki Yamamoto, Masaaki Miyauchi, Moritsugu Kimura, Takehiko Wada, Masafumi Fukagawa   +11 more
doaj   +1 more source

Chemical shift perturbation analysis of integrin α1-TMC upon the addition of integrin β1-TMC.

, 2013
HSQC titration of 15N-labeled integrin α1-TMC with addition of unlabeled integrin β1-TMC. Some peaks of integrin α1-TMC are missing at elevated integrin β1-TMC concentrations (marked with residue names).
Xiaoxi Liu (292827), Fangming Wu (278816), Chaohua Lai (408552), Changlin Tian (278817)   +3 more
core   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Expression and cell membrane localization of heterologous β1 integrin.

, 2012
(A) Quantitative RT-PCR for quantification of β1 integrin mRNA performed on total mRNA extracted from cultured keratinocytes derived from a non-transgenic pig (#2990) and the six hITGB1 transgenic pigs, normalized to endogenous β-actin.
Lars Svensson (165567), Ying Liu (18461), Maria Nascimento Primo (165546), Jacob Giehm Mikkelsen (124821), Frederik Dagnæs-Hansen (165563), Henrik Callesen (165577), Nicklas Heine Staunstrup (124813), Stig Purup (165560), Mette Schmidt (165558), Peter M. Kragh (165552), Johannes Madsen (165540), Rong Li (72042), Thomas K. Petersen (165573), Juan Li (146180), Lars Bolund (14173)   +14 more
core   +1 more source