Results 81 to 90 of about 56,023 (262)

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, EarlyView.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source

Integrin-dependent osteoblast differentiation.

, 2017
Levels of chondrogenic (A) and osteoblastic (B) mRNA. (C-F) Cell number and osteogenic protein levels in wild type human MSCs (WT) and silenced integrin β1 MSCs (shITGB1) cultured on surfaces of varying stiffness. *P P
Erin M. Lee (3663484), Kathryn Smith (201924), Rene Olivares-Navarrete (663118), Barbara D. Boyan (663120), Sharon L. Hyzy (745981), Joseph K. Williams (3663481), Zvi Schwartz (663119), Ken Gall (3663487), Maryam Doroudi (3663490)   +8 more
core   +1 more source

How Neuromorphic Microstructures Control In Vitro Early‐Stage Neuronal Outgrowth

Advanced Science, EarlyView.
Biomimetic approach to neuronal interaction with neuromorphic microstructures. ABSTRACT Neuromorphic biomaterials represent a novel class of materials designed to replicate the architecture and functionality of neuronal structures, offering new opportunities in tissue engineering and bioelectronics.
Claudia Latte Bovio, Esther Matamoros, Valentina Mollo, Anna Mariano, Valeria Criscuolo, Francesca Santoro   +5 more
wiley   +1 more source

Decreased β1 integrin under hypoxia.

, 2016
Representative fluorescent micrographs of β1 integrin abundance under normoxia (A) or hypoxia (C) with the mouse IgG1 isotype control (B and D). Green: β1 integrin, Blue: DAPI.
Hassan Y. Naim (167479), Petra Dersch (183557), Nathalie E. Zeitouni (843137), Maren von Köckritz-Blickwede (311689)   +3 more
core   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling

Molecular Cancer, 2009
Background Phosphatase of regenerating liver-3 (PRL-3) plays a causative role in tumor metastasis, but the underlying mechanisms are not well understood. In our previous study, we observed that PRL-3 could decrease tyrosine phosphorylation of integrin β1
Wu Jian, Jiang Beihai, Lian Shenyi, Meng Lin, Qu Like, Li Weijun, Xing Xiaofang, Peng Lirong, Shou Chengchao   +8 more
doaj   +1 more source

Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-β-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells. [PDF]

PLoS ONE, 2015
Epithelial-to-mesenchymal transition (EMT) plays a critical role in cancer metastasis, and is regulated by growth factors such as transforming growth factor β (TGF-β) and fibroblast growth factors (FGF) secreted from the stromal and tumor cells. However,
Seiji Mori, Moe Kodaira, Ayano Ito, Mika Okazaki, Naomasa Kawaguchi, Yoshinosuke Hamada, Yoshikazu Takada, Nariaki Matsuura   +7 more
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

C1GALT1 regulates integrin β1 activity and signaling.

, 2014
(a) The activity of integrin β1 was enhanced in C1GALT1 overexpressing cells. Mock and C1GALT1 transfectants were analyzed by flow cytometry with anti-integrin β1 antibody (left) or anti-activated integrin β1 (HUTS-21) antibody (right).
I-Rue Lai (608592), Yao-Ming Wu (386205), Chia-Hua Chen (234886), Hong-Shiee Lai (301362), Min-Chuan Huang (281425), Rey-Heng Hu (135326), Chiung-Hui Liu (291005), Miao-Juei Huang (281421)   +7 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source