Results 81 to 90 of about 145,582 (257)

PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling

Molecular Cancer, 2009
Background Phosphatase of regenerating liver-3 (PRL-3) plays a causative role in tumor metastasis, but the underlying mechanisms are not well understood. In our previous study, we observed that PRL-3 could decrease tyrosine phosphorylation of integrin β1
Wu Jian, Jiang Beihai, Lian Shenyi, Meng Lin, Qu Like, Li Weijun, Xing Xiaofang, Peng Lirong, Shou Chengchao   +8 more
doaj   +1 more source

Confocal laser scanning micrographs show the double-fluorescence of integrin β1-FAK (A–I), and integrin β1-WT1 (J–R).

, 2014
Under normotensive condition, integrin β1 showed intense staining along the GBM of the glomeruli (A, arrows). FAK was distributed in the cytoplasm and nuclei of the podocytes evenly (B, arrows).
Juan Wang (115708), Zilong Li (245221), Xiaoli Yuan (359671), Xiaohui Yin (547490), Xiaoyue Zhai (547491), Lining Wang (547492), Wei Wang (17594), Kai Li (205203)   +7 more
core   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Prognostic value of β1 integrin expression in colorectal liver metastases [PDF]

, 2015
Integrins are cell surface adhesion molecules (CAM) that regulate via intercellular and cell-matrix signaling various cellular processes including wound healing, cell differentiation, division, growth, migration and metastatic dissemination.
Vassos, Nikolaos, Merkel, Susanne, Feiersinger, Fabian, Geppert, Carol, Croner, Roland S., Rau, Tilman, Stürzl, Michael, Hohenberger, Werner   +7 more
core   +1 more source

Integrin-dependent osteoblast differentiation.

, 2017
Levels of chondrogenic (A) and osteoblastic (B) mRNA. (C-F) Cell number and osteogenic protein levels in wild type human MSCs (WT) and silenced integrin β1 MSCs (shITGB1) cultured on surfaces of varying stiffness. *P P
Erin M. Lee (3663484), Kathryn Smith (201924), Rene Olivares-Navarrete (663118), Barbara D. Boyan (663120), Sharon L. Hyzy (745981), Joseph K. Williams (3663481), Zvi Schwartz (663119), Ken Gall (3663487), Maryam Doroudi (3663490)   +8 more
core   +1 more source

Arrayed Magnetic Accelerator Synergistically Enhances Orthodontic Tooth Movement via Microtubule Assembly‐Mediated Periodontal Remodeling

Advanced Science, EarlyView.
Mechanical orthodontic treatment for malocclusion is limited by slow remodeling and risks due to poor biomechanical sensing. This study shows that static magnetic fields (SMFs) enhance mechanical sensation in periodontal ligament cells, promoting inflammation and osteoclast activity.
Yiling Lou, Jiwei Sun, Peng Chen, Caihong Mao, Junyuan Zhang, Haoqi Lei, Xiaoqing Han, Yaxuan Zhang, Yuheng Jiang, Yulin Jia, Bin Su, Lili Chen   +11 more
wiley   +1 more source

Upregulation of α3β1-Integrin in Podocytes in Early-Stage Diabetic Nephropathy

Journal of Diabetes Research, 2016
Background. Podocyte injury plays an important role in the onset and progression of diabetic nephropathy (DN). Downregulation of α3β1-integrin expression in podocytes is thought to be associated with podocyte detachment from the glomerular basement ...
Kaichiro Sawada, Masao Toyoda, Noriko Kaneyama, Sawako Shiraiwa, Hitomi Moriya, Han Miyatake, Eitaro Tanaka, Naoyuki Yamamoto, Masaaki Miyauchi, Moritsugu Kimura, Takehiko Wada, Masafumi Fukagawa   +11 more
doaj   +1 more source

MicroRNA- 130b suppresses migration and invasion of colorectal cancer cells through downregulation of integrin β1 [corrected].

PLoS ONE, 2014
MicroRNA 130b (miR-130b) is significantly dysregulated in various human tumor types. In this study, using a microarray assay, we characterized the upregulation of miR-130b expression in colorectal cancer (CRC) specimens.
Yanyang Zhao, Gang Miao, Yao Li, Tomoya Isaji, Jianguo Gu, Jian Li, Ruomei Qi   +6 more
doaj   +1 more source

Chemical shift perturbation analysis of integrin α1-TMC upon the addition of integrin β1-TMC.

, 2013
HSQC titration of 15N-labeled integrin α1-TMC with addition of unlabeled integrin β1-TMC. Some peaks of integrin α1-TMC are missing at elevated integrin β1-TMC concentrations (marked with residue names).
Xiaoxi Liu (292827), Fangming Wu (278816), Chaohua Lai (408552), Changlin Tian (278817)   +3 more
core   +1 more source