Results 121 to 130 of about 56,023 (262)

GGA2 and RAB13 promote activity-dependent β1-integrin recycling

, 2019
β1-integrins mediate cell–matrix interactions and their trafficking is important in the dynamic regulation of cell adhesion, migration and malignant processes, including cancer cell invasion.
Icha, Jaroslav, Arjonen, Antti, Paatero, Ilkka, Hamidi, Hellyeh, Pietilä, Mika, Sahgal, Pranshu, Rokka, Anne, Ivaska, Johanna, Alanko, Jonna H ; https://orcid.org/   +8 more
core   +1 more source

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

Genetische Unterbrechung der Kindlin-3/β1-Integrin Interaktion führt zu reduzierter β1-Integrin abhängigen Plättchenadhäsion und Granulasekretion

, 2013
The affinity state of integrins is regulated by two cytoplasmic integrin binding proteins: talin and kindlin. Loss of either of them results in inactive integrins in various cell types.
Petzold, Tobias
core  

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

Schematic drawing for differential regulation via β1 integrin antibodies.

, 2013
Comparison of the influences of activated and inhibited signaling via β1 integrin specific antibodies on the protein expression of different immunoreactivity markers.
Martin Humphries (502590), Tamás Bíró (347227), Stephan Tiede (344267), Jennifer E. Kloepper (452877), Arzu Yay (502589), Ralf Paus (261703), Nancy Ernst (502588)   +6 more
core   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Lighting up Macrophage Reprogramming Assists Immunosuppressive Niche Modulation in Primary Tumors and Tumor‐Draining Lymph Nodes of Breast Cancer

Advanced Science, EarlyView.
This study develops an intelligent NIR‐II‐responsive nanoplatform to combat immunosuppression in breast cancer. It enables real‐time visualization of macrophage activity via “off‐on” fluorescence while simultaneously reprogramming macrophages through the CSF‐1R and CD47‐SIRPα pathways.
Yingbo Li, Di Chang, Jie Yang, Ying Bai, Min Chen, Daoshuang Li, Zuoyu Xu, Jiaxin Yuan, Xiaoxuan Xu, Zhiqi Zhang, Yize Li, Zixin Chen, Jinbing Xie, Zebin Xiao, Shenghong Ju   +14 more
wiley   +1 more source

Flow cytometry analysis about E-cadherin, integrin β1 and integrin β3.

, 2012
Flow cytometry analysis about E-cadherin, integrin β1 and integrin β3.
Bo Xi (129419), Jie Zhang (64655), Jie Chen (5892), Jian Xue (145753), Yueran Zhao (145760), Dan He (145755), Mei Wang (130842)   +6 more
core   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Endothelial β1 integrin-mediated adaptation to myocardial ischemia

, 2020
Background: Short episodes of myocardial ischemia can protect from myocardial infarction. However, the role of endothelial β1 integrin in these cardioprotective ischemic events is largely unknown.Objective: In this study we investigated whether ...
HEISS, CHRISTIAN, Lammert, Eckhard, Lewandowska, Oksana, Benkhoff, Marcel, KELM, MALTE, Henning, Carina, Follert, Paula, Flögel, Ulrich, Ayhan, Aysel, Branopolskia, Anna   +9 more
core