Results 181 to 190 of about 86,429 (265)

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Phosphomimetic Thrombospondin-1 Modulates Integrin β1-FAK Signaling and Vascular Cell Functions. [PDF]

Biomolecules
Raya A, Bécsi B, Boratkó A.
europepmc   +1 more source

Higher Matrix Stiffness Upregulates Osteopontin Expression in Hepatocellular Carcinoma Cells Mediated by Integrin β1/GSK3β/β-Catenin Signaling Pathway

, 2015
Yang You, Qiongdan Zheng, Yinying Dong, Yaohui Wang, Lan Zhang, Tong‐Chun Xue, Xiaoying Xie, Chao Hu, Zhiming Wang, Rongxin Chen, Yanhong Wang, Jiefeng Cui, Zhenggang Ren   +12 more
openalex   +2 more sources

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles. [PDF]

J Cell Biol
Rodrigues-Junior DM, Sáez-Ibáñez AR, Terabayashi T, Daubel N, Mäkinen T, Idevall-Hagren O, Moustakas A, Ferby I.   +7 more
europepmc   +1 more source

Supplementary Movie 2 from β1 Integrin Targeting Potentiates Antiangiogenic Therapy and Inhibits the Growth of Bevacizumab-Resistant Glioblastoma

, 2023
W. Shawn Carbonell, Michael DeLay, Arman Jahangiri, Catherine C. Park, Manish K. Aghi   +4 more
openalex   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction‐Associated Steatohepatitis

Hepatology Research, EarlyView.
Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura, Aya Naiki‐Ito, Xiaochen Kuang, Akihiro Murakami, Masayuki Komura, Takanori Suzuki, Hiroyuki Kato, Yuko Nagayasu, Kentaro Matsuura, Kei Fujiwara, Hiromi Kataoka, Satoru Takahashi   +11 more
wiley   +1 more source

GATA3 promotes ferroptosis resistance by repressing integrin β1 signaling. [PDF]

Proc Natl Acad Sci U S A
Karner ER, Wang M, Goel HL, Mercurio AM.
europepmc   +1 more source

Galactomyces ferment filtrate upregulates anchoring junctions and stabilizes actin to maintain the Young's modulus of skin cells in vitro

International Journal of Cosmetic Science, EarlyView.
Ageing causes actin cytoskeleton disorganization, a reduction in cellular components associated with the actin cytoskeleton and focal adhesions, and a reduction in skin firmness. Galactomyces ferment filtrate boosts actin stability, increases expression of anchoring junction proteins, including focal adhesions and protects against loss of firmness ...
Steph Crabtree, Bradley B. Jarrold, Olivia Kent, Matthew C. Ehrman, Timothy J. Hawkins, Viktor Korolchuk, Camila Pereira Braga, John M. Snowball, Makio Tamura, Tomohiro Hakozaki, Akira Matsubara, John E. Oblong, Max Brown   +12 more
wiley   +1 more source