Results 181 to 190 of about 234,137 (355)
Postnatal β1 Integrin Deficiency in Pancreatic Beta-Cells Impairs Function and Survival
, 2017 Integrin β1 is essential for pancreatic beta-cell development and maintenance throughout life in rodents and human fetal islets. However, the effects of a postnatal β1 integrin knockout (β1KO) specific to pancreatic beta-cells of mice is undetermined. We generated mice with CreERT recombinase specific to the mouse insulin promoter (MIP), allowing us to
openaire +1 more source
RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics
Advanced Science, EarlyView.RAB5A‐mediated unjamming enhances active wetting through distinct biomechanical processes: a) upregulation of specific integrin subunits, enhanced focal adhesions kinetics and activity; b) supracellular organization relying on nanoscale integrin clustering, and the formation of a stiff and collective actin cable; and c) softening of the spheroid core ...
Grégoire Lemahieu +19 more
wiley +1 more source
β1 Integrin- and Proteoglycan-Mediated Stimulation of T Lymphoma Cell Adhesion and Mitogen-Activated Protein Kinase Signaling by Thrombospondin-1 and Thrombospondin-1 Peptides [PDF]
, 1999 Katherine Wilson +4 more
openalex +1 more source
A Mechanism for Ventricular Expansion in Communicating Hydrocephalus [PDF]
, 2009 This report investigates a new possible molecular mechanism for the pathogenesis of hydrocephalus. New research by Dr. Miles Johnston has found that the injection of anti beta_1 integrin antibodies into the ventricle of rats causes a drop in parenchymal ...
Begg, R., Wilkie, K.
core
Integrin β1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo [PDF]
Integrin β1 is both overexpressed and in an ‘active' conformation in vulval squamous cell carcinomas (VSCCs) compared to matched normal skin. To investigate the significance of integrin β1 deregulation we stably knocked-down integrin β1 expression in the
A Luque +42 more
core +2 more sources
Advanced Science, EarlyView.CCS‐RSF@PRP hydrogel is engineered to structurally and functionally mimic the blood clot by integrating PPR, CCS, and RSF nanofibers through in situ activation of PRP. In a rat periodontitis model, CCS‐RSF@PRP hydrogel effectively promotes periodontal tissue repair, attributing to neutralizing the multiple proinflammatory mediators, thus rebuilding a ...
Yini Huangfu +14 more
wiley +1 more source
Hypothermia Attenuates β1 Integrin Expression on Neutrophils in an Animal Model of Meningitis [PDF]
, 1999 Mark E. Rowin +2 more
openalex +1 more source
Advanced Science, EarlyView.Fusobacterium nucleatum (Fn) enrichment has been identified in colorectal cancer and its liver metastases. This study develops neutrophil‐mimicking nanoparticles with multiple targeting capabilities encapsulating metronidazole and oxaliplatin for antibacterial and anticancer purposes. This approach reverses the epithelial mesenchymal transition process
Yanan Niu +7 more
wiley +1 more source
The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
Advanced Science, EarlyView.This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen +6 more
wiley +1 more source
Cell Reports, 2020 Summary: Cancer cell-derived secretomes have been documented to play critical roles in cancer progression. Intriguingly, alternative extracellular roles of intracellular proteins are involved in various steps of tumor progression, which can offer ...
Caihong Wang +7 more
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