β1-Integrin and PTEN control the phosphorylation of protein kinase C [PDF]
, 2000 Davey B. PAREKH +6 more
openalex +2 more sources
Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer
Cell Reports, 2019 Summary: Lymphatic vasculature is crucial for metastasis in triple-negative breast cancer (TNBC); however, cellular and molecular drivers controlling lymphovascular metastasis are poorly understood. We define a macrophage-dependent signaling cascade that
Rachel Evans +22 more
doaj
β1-integrin∕FAK Initiated MAPK/ERK Pathway Regulates Human Fetal Islet Cell Development and Survival
, 2006 βl integrin and collagen matrix interactions regulate cell survival by associating with FAK and initiating MAPK/ERK signaling, but little is known about these pathways during human fetal islet ontogeny. This study investigated whether βl integrin/FAK activation of the MAPK/ERK pathway is involved in regulating human fetal islet cell survival and ...
openaire +1 more source
Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. [PDF]
, 2012 Aging reduces the number of mesenchymal stem cells (MSCs) that can differentiate into osteoblasts in the bone marrow, which leads to impairment of osteogenesis.
Guan, Min +11 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.The hypothesis diagram illustrates the function and mechanism of circNR3C2: circNR3C2 overexpression can up‐regulate COL2, Aggrecan and SOX9 expression, and regulate chondrogenic differentiation of hADSCs by targeting hsa‐miR‐647. Abstract Background Human adipose‐derived stem cells (hADSCs) are seed cells with application prospects in cartilage repair.
Dabiao Hou +5 more
wiley +1 more source
Functional β1-Integrins Release the Suppression of Fibronectin Matrix Assembly by Vitronectin [PDF]
, 1999 Qinghong Zhang +5 more
openalex +1 more source
Integrin β1 in Adipose-Derived Stem Cells Accelerates Wound Healing via Activating PI3K/AKT Pathway
Tissue Engineering and Regenerative Medicine, 2020 Qihong Wang +5 more
semanticscholar +1 more source
Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects
Animal Models and Experimental Medicine, EarlyView.This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang +5 more
wiley +1 more source
Activated Lymphocytes Promote Endothelial Cell Detachment from Matrix: A Role for Modulation of Endothelial Cell β1 Integrin Affinity [PDF]
, 1999 Cecile Phan +4 more
openalex +1 more source