Results 231 to 240 of about 145,582 (257)

Nidogen-1 suppresses cell proliferation, migration, and glycolysis via integrin β1-mediated HIF-1α downregulation in triple-negative breast cancer. [PDF]

Sci Rep
Lee JH, Son S, Ko Y, Lim H, Lee M, Kang MG, Kim H, Lee KM, Shin I.   +8 more
europepmc   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Intracellular mechanosensation in intestinal smooth muscle: Piezo1 complexes amplify signalling beyond the surface

The Journal of Physiology, EarlyView.
Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at the sarcoplasmic reticulum (SR)–plasma membrane junction. Within this sensor–amplifier–effector axis intra‐Piezo1 is the sensor that detects force at the SR,
Geoanna M. Bautista, Declan Manning, Emily C. Lieu, Stephanie I. Ugochukwu, Collin Matsumoto, Joshua P. Tulman, Miguel Martin‐Aragon Baudel, Nuria Daghbouche‐Rubio, Steven J. McElroy, Sal A. Baker, Manuel F. Navedo, L. Fernando Santana   +11 more
wiley   +1 more source

Regulating Integrin β1 to Restore Gonadotropin-Releasing Hormone-Tanycyte Unit Function in Polycystic Ovary Syndrome-Related Hypothalamic Dysregulation. [PDF]

Research (Wash D C)
Wang Y, Tong X, Xiao Y, Wang Y, Hu W, Lu W, Chen Y, Li J, Gao W, Gao H, Tian Y, Dai S, Feng Y.   +12 more
europepmc   +1 more source

Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization. [PDF]

Commun Biol
Wang G, Peng T, Chen L, Xiong K, Ju L, Qian K, Zhang Y, Xiao Y, Wang X.   +8 more
europepmc   +1 more source

Correction: Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer.

Elife
Zhang Y, Sun L, Li H, Ai L, Ma Q, Qiao X, Yang J, Zhang H, Ou X, Wang Y, Chen G, Xue J, Zhu X, Zhao Y, Yang Y, Liu C.   +15 more
europepmc   +1 more source

Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease. [PDF]

Nat Commun
Elwakiel A, Gupta D, Rana R, Manoharan J, Al-Dabet MM, Ambreen S, Fatima S, Zimmermann S, Mathew A, Li Z, Singh K, Gupta A, Pal S, Sulaj A, Kopf S, Schwab C, Baber R, Geffers R, Götze T, Alo B, Lamers C, Kluge P, Kuenze G, Kohli S, Renné T, Shahzad K, Isermann B.   +26 more
europepmc   +1 more source

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Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions

Nature Reviews Molecular Cell Biology, 2022
Pakorn Kanchanawong, David A Calderwood
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The final steps of integrin activation: the end game

Nature Reviews Molecular Cell Biology, 2010
Mark H Ginsberg, Sanford J Shattil, Chungho Kim   +2 more
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Integrins as biomechanical sensors of the microenvironment

Nature Reviews Molecular Cell Biology, 2019
Pere Roca-cusachs, Jenny Z Kechagia, Johanna Ivaska   +2 more
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