Results 191 to 200 of about 210,881 (328)

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin) [PDF]

, 1994
EU Saelman, H K Nieuwenhuis, KM Hese, PG de Groot, HF Heijnen, E.H. Sage, Sybil B. Williams, Laurie P. McKeown, H. R. Gralnick, J J Sixma   +9 more
openalex   +1 more source

Mechanochemistry: Fundamental Principles and Applications

Advanced Science, EarlyView.
In this review, the physicochemical principles of mechanochemistry are first clarified. Based on this foundation, the research basis and cutting‐edge scientific achievements in four areas are introduced: solid‐state organic chemistry, polymers, interface science, and biomechanochemistry.
Liang Dong, Luofei Li, Huiyan Chen, Yi Cao, Hai Lei   +4 more
wiley   +1 more source

Rh-related antigen CD47 is the signal-transducer integrin-associated protein.

, 1994
Frederik P. Lindberg, Douglas M. Lublin, Marilyn J. Telen, Rosalie Veile, Y E Miller, Helen Donis-Keller, Eric J. Brown   +6 more
openalex   +1 more source

Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha 6 subunit is essential for epithelial polarization in developing kidney tubules. [PDF]

, 1990
Lydia Sorokin, Arnoud Sonnenberg, Monique Aumailley, Rupert Timpl, Peter Ekblom   +4 more
openalex   +1 more source

Fibronectin Fibers Progressively Lose Their Tension in Invasive Human Breast Carcinoma while Being Tensed in DCIS and Healthy Breast Tissue

Advanced Science, EarlyView.
Extracellular matrix remodeling is crucial in cancer progression. Using a peptide to probe the tension of ECM fibers, it was found that Fibronectin fibers gradually lose tension as human breast carcinoma progresses, while their tension is maintained in ductal carcinoma in situ (DCIS), the non‐invasive precursor of breast cancer. This loss of tension is
Arnaud Miéville, Charlotte M. Fonta, Cornelia Leo, Lucine Christe, Jörg Goldhahn, Gad Singer, Viola Vogel   +6 more
wiley   +1 more source

The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 beta subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site. [PDF]

, 1991
Margaret L. Hibbs, Scott Jakes, Steven A. Stacker, Robert W. Wallace, Timothy A. Springer   +4 more
openalex   +1 more source

Age-Related Dysregulation of α5β1 and αvβ3 Integrin Activity Alters Contractile Properties of Trabecular Meshwork Cells. [PDF]

Invest Ophthalmol Vis Sci
Johns KL, Faralli JA, Filla MS, Shah NS, Sun YY, Keller KE, Peters DM.   +6 more
europepmc   +1 more source

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage.

, 1992
Joaquı́n Teixidó, Christina M. Parker, Paul D. Kassner, Martin E. Hemler   +3 more
openalex   +1 more source