Results 251 to 260 of about 210,881 (328)

Inside a Metastatic Fracture: Molecular Bases and New Potential Therapeutic Targets. [PDF]

Cancer Med
Bruschi A, Sambri A, Fiore M, Bubbico E, Scollo C, Pace A, Zunarelli R, Montanari A, Cappelli A, Di Prinzio L, De Paolis M.   +10 more
europepmc   +1 more source

Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6

Advanced Science, EarlyView.
Extracellular matrix compliance plays a critical role in the regulation of integrin‐mediated adhesion and cell motility. Here, it is reported that strengthening the kindlin2‐integrin β6 interaction overcomes the dependence on extracellular substrate stiffness and promotes integrin β6‐mediated cell migration.
Wan Ning Lee, Jiamin Li, Nan‐Peng Chen, Cheng‐han Yu   +3 more
wiley   +1 more source

Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras.

, 1994
Steven K. Akiyama, S S Yamada, Kenneth M. Yamada, Susan E. LaFlamme   +3 more
openalex   +1 more source

Integrin and Its Associated Proteins as a Mediator for Mechano-Signal Transduction. [PDF]

Biomolecules
Katoh K.
europepmc   +1 more source

Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection

Advanced Science, EarlyView.
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng, Yansong Wang, Haoyue Huang, Yinglong Ding, Jun Wang, Meili Liu, Kun Song, Lianbo Shao, You Yu, Ziying Yang, Zhenya Shen   +10 more
wiley   +1 more source

“Inside-out” signal transduction inhibited by isolated integrin cytoplasmic domains

, 1994
Y.P. Chen, Timothy E. O’Toole, T. Shipley, Jane Forsyth, Susan E. LaFlamme, Kenneth M. Yamada, Sanford J. Shattil, Mark H. Ginsberg   +7 more
openalex   +1 more source

A Review of Talin- and Integrin-Dependent Molecular Mechanisms in Cancer Invasion and Metastasis. [PDF]

Int J Mol Sci
Baster Z, Russell L, Rajfur Z.
europepmc   +1 more source

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Bacterial internalization mediated by beta 1 chain integrins is determined by ligand affinity and receptor density.

, 1993
Guy Tran Van Nhieu, Ralph R. Isberg
openalex   +1 more source

Integrins as Key Mediators of Metastasis. [PDF]

Int J Mol Sci
Cáceres-Calle D, Torre-Cea I, Marcos-Zazo L, Carrera-Aguado I, Guerra-Paes E, Berlana-Galán P, Muñoz-Félix JM, Sánchez-Juanes F.   +7 more
europepmc   +1 more source