Results 281 to 290 of about 221,644 (354)

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

The Reciprocal Relationship Between Cell Adhesion Molecules and Reactive Oxygen Species. [PDF]

Cells
Al-Hadi M, Nikonenko AG, Sytnyk V.
europepmc   +1 more source

Integrins

Japanese Journal of Thrombosis and Hemostasis, 2015
openaire   +2 more sources

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Recombinant RGD-Apoptins Decrease Human Melanoma Cell Viability. [PDF]

Int J Mol Sci
Shirokov D, Lepekhina D, Manuvera V, Bogomiakova M, Strokach A, Kazakova A, Arapidi G, Lazarev V.   +7 more
europepmc   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

If Plan A Does Not Work: The CD47 Ectodomain as a Target for Immune Tolerance. [PDF]

Cells
Montero E, Isenberg JS.
europepmc   +1 more source

Integrin β1–rich extracellular vesicles of kidney recruit Fn1+ macrophages to aggravate ischemia-reperfusion–induced inflammation

Wenjuan Wang, Xuejing Ren, Xiangmei Chen, Quan Hong, Guangyan Cai   +4 more
openalex   +1 more source

Catalyst‐Free Collagen Filament Crosslinking for Engineering Anisotropic and Mechanically Robust Tissue Scaffolds

Advanced Science, EarlyView.
A bioorthogonal rhodamine/PEG crosslinking strategy is introduced to engineer dense collagen hydrogels with high mechanical resilience and cytocompatibility. Integration with wet‐spinning enables the fabrication of uniaxially aligned, cell‐laden collagen filaments that activate mechanotransductive signaling and support functional muscle regeneration in
JuYeon Kim, Hanjun Hwangbo, ByungJoon Choi, Dogeon Yoon, GeunHyung Kim   +4 more
wiley   +1 more source

Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche. [PDF]

Elife
Masson C, Scandola C, Rinckel JY, Proamer F, Janus-Bell E, Batool F, Osmani N, Goetz JG, Mallo L, Brouard N, Leon C, Bornert A, Poincloux R, Destaing O, Mansson A, Qian H, Lehmann M, Eckly A.   +17 more
europepmc   +1 more source