Results 291 to 300 of about 221,644 (354)

Spatio‐Temporal Proteomic Landscape Reveals Early Warning Signals of Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
This study constructs a proteomic atlas of esophageal squamous cell carcinoma (ESCC) progression using esophageal biopsy samples. It identifies moderate dysplasia as the critical turning stage and a seven‐protein panel for early detection. Functionally, GBP6 loss promotes ESCC progression via cell cycle and epithelial‐mesenchymal transition (EMT ...
Xumiao Li, Jie Yuan, Min Gao, Jibin Liu, Qinqin Wang, Yaqi Zhang, Mingtao Cao, Xiaolin Hu, Hui Yang, Jun Li, Chen Li, Xiaoguang Li, Hui Wang   +12 more
wiley   +1 more source

A genome-wide genetic screen reveals the P2Y2-integrin axis as a stabilizer of EGFR mutants in non-small cell lung cancer (NSCLC). [PDF]

Sci Adv
Du Y, Wang W, Goh HC, Vaiyapuri TS, Raju A, Hsiao YC, Wang CC, Agrawal V, Mohideen NF, Mohd Mazian NB, Karatekin F, Wang WK, Lakshmanan M, Gupta K, Chang H, Le Guezennec X, Bard F, Tan DSW, Tergaonkar V, Hung MC, Liu X, Hong W, Boopathy GTK.   +22 more
europepmc   +1 more source

A Bioinstructive Injectable Hydrogel for Enhancing Intrinsic Regeneration through Cell Recruitment and Training

Advanced Science, EarlyView.
A bioinstructive injectable hydrogel enables sustained release of stromal cell–derived factor‐1 alpha (SDF‐1α) and stable retention of laminin through ionic and hydrophobic interactions. This dual‐signaling matrix promotes endogenous stem cell recruitment and training, supports angiogenesis, and enhances intrinsic regenerative processes in ischemic ...
Yurim Kim, Young‐Min Kim
wiley   +1 more source

Mechanochemical regulation of organoid morphogenesis: Integrated signaling circuits in engineered microenvironments. [PDF]

Mater Today Bio
Zhang X, Zhao Y, Mao L, Wang Q, Huang P.
europepmc   +1 more source

Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early‐Onset Colorectal Cancer

Advanced Science, EarlyView.
This study identifies a unique physical signature of colorectal cancer in younger adults: their tissues are mechanically stiffer than those in older patients with the same cancer. Furthermore, stromal remodeling in early‐onset colorectal cancer promotes epithelial mechanotransduction and proliferation, showing how mechanical alterations in the tissue ...
Nicole C. Huning, Munir H. Buhaya, Victor V. Nguyen, Afeefah Khazi‐Syed, Haider A. Ali, Adil Khan, Angela Fan, Robert C. Fisher, Zhikai Chi, Indu Raman, Guangchun Chen, Chengsong Zhu, Mengxi Yu, Andrew R. Jamieson, Sara Roccabianca, Victor D. Varner, Cheryl M. Lewis, Emina H. Huang, Jacopo Ferruzzi   +18 more
wiley   +1 more source

The Role and Application of MAdCAM-1/α4β7-Induced Lymphocyte Migration in Inflammatory Enterohepatic Diseases. [PDF]

Biomedicines
Yu C, Pan Y, Mao A, Zhao Y, Liu Q, Hu Y.
europepmc   +1 more source

CD147 at the crossroads of glycoprotein networks, metabolic reprogramming, and metastatic progression. [PDF]

Front Immunol
Su TS, Wang JW, Su YL, Lin MH, Chiou HC.
europepmc   +1 more source

Critical Role of the Endothelial αV/β5 Integrin Receptor Signaling Pathway in Promoting Irisin-induced Hippocampal BDNF Expression. [PDF]

Mol Neurobiol
C L, A Q, A M, S L, E F, P G, A PT.
europepmc   +1 more source

The Urokinase-Type Plasminogen Activator Receptor (uPAR) as a Mediator of Physiological and Pathological Processes: Potential Therapeutic Strategies. [PDF]

Cancers (Basel)
Iftikhar A, Mahmood N, Rabbani SA.
europepmc   +1 more source

Depletion of all platelet integrins impacts hemostasis, thrombosis, and tumor metastasis. [PDF]

iScience
Janus-Bell E, Liboni C, Yakusheva A, Mittelheisser V, Mouriaux C, Bourdon C, Bochler L, Hyenne V, Garcia-Leon M, Lefebvre O, Goetz JG, Mangin PH.   +11 more
europepmc   +1 more source