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Current Opinion in Cell Biology, 1997
The loss of integrin-mediated cell-matrix contact induces apoptosis ('anoikis') in certain cell types. Recently it has been shown that protein kinase signaling pathways control anoikis both positively and negatively. Focal adhesion kinase, when activated by integrins, can suppress anoikis.
S. Frisch, E. Ruoslahti
semanticscholar +4 more sources
The loss of integrin-mediated cell-matrix contact induces apoptosis ('anoikis') in certain cell types. Recently it has been shown that protein kinase signaling pathways control anoikis both positively and negatively. Focal adhesion kinase, when activated by integrins, can suppress anoikis.
S. Frisch, E. Ruoslahti
semanticscholar +4 more sources
Integrins as biomechanical sensors of the microenvironment
Nature Reviews Molecular Cell Biology, 2019Johanna Ivaska, Pere Roca-cusachs
exaly +2 more sources
Role of integrins in cell invasion and migration
Nature Reviews Cancer, 2002J. Hood, D. Cheresh
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New perspectives in cell adhesion: RGD and integrins.
Science, 1987Rapid progress has been made in the understanding of the molecular interactions that result in cell adhesion. Many adhesive proteins present in extracellular matrices and in the blood contain the tripeptide arginine-glycine-aspartic acid (RGD) as their ...
E. Ruoslahti, Pierschbacher
semanticscholar +1 more source
RGD and other recognition sequences for integrins.
Annual Review of Cell and Developmental Biology, 1996Proteins that contain the Arg-Gly-Asp (RGD) attachment site, together with the integrins that serve as receptors for them, constitute a major recognition system for cell adhesion. The RGD sequence is the cell attachment site of a large number of adhesive
E. Ruoslahti
semanticscholar +1 more source
Integrins and signal transduction pathways: the road taken.
Science, 1995Adhesive interactions play critical roles in directing the migration, proliferation, and differentiation of cells; aberrations in such interactions can lead to pathological disorders.
E. Clark, J. Brugge
semanticscholar +1 more source
Seminars in Reproductive Medicine, 2006
Integrins are the major receptors mediating adhesion to the extracellular matrix. Following ligand binding, conformational changes of integrins induce the recruitment of multiple signaling and scaffolding proteins that connect integrin tails to the actin cytoskeleton and permit activation of signaling pathways regulating cell proliferation, apoptosis ...
Monniaux, Danielle +5 more
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Integrins are the major receptors mediating adhesion to the extracellular matrix. Following ligand binding, conformational changes of integrins induce the recruitment of multiple signaling and scaffolding proteins that connect integrin tails to the actin cytoskeleton and permit activation of signaling pathways regulating cell proliferation, apoptosis ...
Monniaux, Danielle +5 more
openaire +3 more sources
Current Opinion in Cell Biology, 1996
The past year or two has seen great advances in the elucidation of significant roles for integrins in cancer cells. These include roles in signal transduction, gene expression, proliferation, apoptosis regulation, invasion and metastasis, and angiogenesis. In particular, integrin alphavbeta3 has been implicated in the neovascularization of tumors.
David A. Cheresh, Judith A. Varner
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The past year or two has seen great advances in the elucidation of significant roles for integrins in cancer cells. These include roles in signal transduction, gene expression, proliferation, apoptosis regulation, invasion and metastasis, and angiogenesis. In particular, integrin alphavbeta3 has been implicated in the neovascularization of tumors.
David A. Cheresh, Judith A. Varner
openaire +3 more sources
Clinical Science, 1996
1. Adhesion is a vital property of cells. It provides a stable environment for cell growth and differentiation and allows cells to migrate. 2. The interaction between cells and their extracellular matrices is also an important factor in the regulation of further protein deposition.
Graham S. Hillis, Alison M. MacLeod
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1. Adhesion is a vital property of cells. It provides a stable environment for cell growth and differentiation and allows cells to migrate. 2. The interaction between cells and their extracellular matrices is also an important factor in the regulation of further protein deposition.
Graham S. Hillis, Alison M. MacLeod
openaire +3 more sources