Results 61 to 70 of about 210,881 (328)

Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis

Molecular Cancer, 2011
Background Although integrins have been implicated in the progression of breast cancer, the exact mechanism whereby they exert this regulation is clearly not understood.
Hazari Siddhartha, Bao Lili, Jain Prachi, Rathinam Rajamani, Baranwal Somesh, Shenouda Sylvia, Wang Yanfang, Dash Srikanta, Alahari Suresh K   +8 more
doaj   +1 more source

β1 integrins mediate the BMP2 dependent transcriptional control of osteoblast differentiation and osteogenesis. [PDF]

PLoS ONE, 2018
Osteoblast differentiation is a highly regulated process that requires coordinated information from both soluble factors and the extracellular matrix. Among these extracellular stimuli, chemical and physical properties of the matrix are sensed through ...
Molly Brunner, Noémie Mandier, Thierry Gautier, Genevieve Chevalier, Anne-Sophie Ribba, Philippe Guardiola, Marc R Block, Daniel Bouvard   +7 more
doaj   +1 more source

Plasticity of hydrogen bond networks regulates mechanochemistry of cell adhesion complexes [PDF]

, 2014
Mechanical forces acting on cell adhesion receptor proteins regulate a range of cellular functions by formation and rupture of non-covalent interactions with ligands. Typically, force decreases the lifetimes of intact complexes (slip-bonds), making the discovery that these lifetimes can also be prolonged ("catch-bonds"), a surprise.
arxiv   +1 more source

Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes [PDF]

, 2007
Adhesion molecules of the integrin beta1 family are thought to be involved in the malignant progression renal cell carcinoma (RCC). Still, it is not clear how they contribute to this process.
Achiwa H, Anastassiou G, Blattner SM, Brenner W, Dufour S, Hegerfeldt Y, Hii CS, Markovic-Lipkovski J, Perlino E, Seftor RE, Yamada S   +10 more
core   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Components of cell-matrix linkage as potential new markers for prostate cancer [PDF]

, 2011
Prostate cancer is one of the most common tumor diseases worldwide. Often being non-aggressive, prostate tumors in these cases do not need immediate treatment.
Eble, Johannes Andreas, Navdaev, Alexey
core   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Chase-and-run dynamics in cell motility and the molecular rupture of interacting active elastic dimers [PDF]

Phys. Rev. E 96, 032407 (2017), 2016
Cell migration in morphogenesis and cancer metastasis typically involves interplay between different cell types. We construct and study a minimal, one-dimensional model comprised of two different motile cells with each cell represented as an active elastic dimer.
arxiv   +1 more source

CD98hc facilitates B cell proliferation and adaptive humoral immunity. [PDF]

, 2009
The proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell-specific deletion of the heavy chain of CD98 (CD98hc) resulted in lower antibody responses due to total ...
A Mondino, AP Warren, AW Freidman, C Brakebusch, CA Fenczik, CA Fenczik, CC Feral, CC Feral, Cecille D Browne, CG Lo, CG Proud, Chloé C Féral, CL Abram, D Torrents, DC Otero, DE White, DM Rose, E Arana, F Esteban, FD Batista, FM Burnet, GW Prager, H Tsumura, J Bertran, J Fernandez-Herrera, J Hasbold, JG Cyster, JH Kehrl, JL Walker, Joseph Cantor, K Hara, K Roovers, KB Lin, KL Wolniak, L Kass, L Van Parijs, LA Diaz Jr., MA Schwartz, Mark H Ginsberg, MD Cooper, ML Motti, NC Henderson, R Zent, Raphael Ruppert, RC Rickert, Reinhard Fässler, RK Assoian, RO Hynes, Robert C Rickert, RT Abraham, SG Tangye, SJ Fleire, T Lammermann, T Uinuk-Ool, TN Sims, TT Lu, Y Shimizu   +56 more
core   +2 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source