Results 11 to 20 of about 8,780 (184)
The Natural History of Integrons [PDF]
Microorganisms, 2021 Integrons were first identified because of their central role in assembling and disseminating antibiotic resistance genes in commensal and pathogenic bacteria. However, these clinically relevant integrons represent only a small proportion of integron diversity.
Timothy M. Ghaly +5 more
openaire +4 more sources
Resistance integrons and super-integrons [PDF]
Clinical Microbiology and Infection, 2004 Integrons are genetic elements composed of a gene encoding an integrase, gene cassettes and an integration site for the gene cassettes (att). The integrase excises and integrates the gene cassettes from and into the integron, but integrons themselves are not mobile. Two groups of integrons are known: resistance integrons and super-integrons. Nearly all
Fluit, A.C., Schmitz, F.-J.
openaire +2 more sources
Resistance integrons: class 1, 2 and 3 integrons [PDF]
Annals of Clinical Microbiology and Antimicrobials, 2015 As recently indiscriminate abuse of existing antibiotics in both clinical and veterinary treatment leads to proliferation of antibiotic resistance in microbes and poses a dilemma for the future treatment of such bacterial infection, antimicrobial resistance has been considered to be one of the currently leading concerns in global public health, and ...
Deng, Yang +9 more
openaire +2 more sources
Integrons in Salmonella Keurmassar, Senegal
Emerging Infectious Diseases, 2004 To the Editor: Infections caused by Salmonella are the primary cause of foodborne diseases; multidrug resistance to Salmonella enterica subsp. enterica is increasing. The selective pressure created by the widespread use of antimicrobial agents in animals and humans as prophylactic and therapeutic agents may have contributed to the dissemination of ...
Amy Gassama-Sow +4 more
doaj +3 more sources
Mobile Genetic Elements, 2012 Integrons are genetic elements first described at the end of the 1980s. Although most integrons were initially described in human clinical isolates, they have now been identified in many non-clinical environments, such as water and soil. Integrons are present in ≈10% of the sequenced bacterial genomes and are frequently linked to mobile genetic ...
Domingues, Sara +2 more
openaire +2 more sources
The evolutionary history of chromosomal super-integrons provides an ancestry for multiresistant integrons [PDF]
Proceedings of the National Academy of Sciences, 2001 Integrons are genetic elements that acquire and exchange exogenous DNA, known as gene cassettes, by a site-specific recombination mechanism. Characterized gene cassettes consist of a target recombination sequence ( attC site) usually associated with a single open reading frame coding for ...
D A, Rowe-Magnus +5 more
openaire +2 more sources
Journal of Pure and Applied Microbiology, 2023 Antimicrobial agents are widely used for treatment of animal and human diseases. Heavy use of antimicrobial agents permits bacteria to develop resistance to these agents specifically when a dose of antibiotic is insufficient or course of treatment is ...
Yathrib Al-Ubaidy, Amjed Alsultan
doaj +1 more source
Novel Gene Cassettes and Integrons [PDF]
Antimicrobial Agents and Chemotherapy, 2001 ABSTRACT An increase in multiresistant Enterobacteriaceae was observed at one of the departments of the University Medical Center Utrecht. Nine different integrons and 17 gene cassettes were found, including the new gene cassette aadA8 . This cassette was highly related to
E D, Peters +4 more
openaire +2 more sources
Characterization of the novel In1059 harbouring VIM gene cassette
Antimicrobial Resistance and Infection Control, 2017 Background VIM-type enzyme encodes the most widely acquired metallo-β-lactamases in Gram- negative bacteria. To obtain current epidemiological data for integrons from enterobacteriae in hospital, the study characterizes the genetic structure in In1059 by
Dongguo Wang +6 more
doaj +1 more source