Results 61 to 70 of about 159,270 (294)

Exomoon Habitability and Tidal Evolution in Low-Mass Star Systems

, 2017
Discoveries of extrasolar planets in the habitable zone (HZ) of their parent star lead to questions about the habitability of massive moons orbiting planets in the HZ. Around low-mass stars, the HZ is much closer to the star than for Sun-like stars.
Armstrong, John C., Heller, René, Zollinger, Rhett R.   +2 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Effects of turbulence structure and urbanization on the heavy haze pollution process [PDF]

Atmospheric Chemistry and Physics, 2019
In this paper, an automated algorithm is developed, which is used to identify the spectral gap during the heavy haze pollution process, reconstruct acquired data, and obtain pure turbulence data.
Y. Ren, H. Zhang, W. Wei, B. Wu, X. Cai, Y. Song   +5 more
doaj   +1 more source

Numerical simulations of the impacts of mountain on oasis effects in arid Central Asia [PDF]

, 2017
The oases in the mountain-basin systems of Central Asia are extremely fragile. Investigating oasis effects and oasis-desert interactions is important for understanding the ecological stability of oases.
De Maeyer, Philippe, Hamdi, Rafiq, Kurban, Alishir, Luo, Geping, Qiu, Yuan, Wang, Xinxin, Zhang, Miao   +6 more
core   +3 more sources

Mathematical modelling of high-intensity heat flux on the elements of heat-shielding composite materials of a spacecraft

Journal of Applied Engineering Science, 2020
The main purpose of this paper is to evaluate the structural response of composite steel-concrete eccentrically buckling-restrained braced frames (BRBFs). The finite element (FE) software ABAQUS is employed to nonlinearly analyse the BRBFs. Comparing the modelling and experimental test results validates the FE modelling method of the BRBF.
Polina Pronina, Ying Sun, Olga Tushavina
openaire   +1 more source

The high-heat flux testing of an interceptive device for an intense proton beam [PDF]

PACS2001. Proceedings of the 2001 Particle Accelerator Conference (Cat. No.01CH37268), 2002
An interceptive device referred to here as a scraper has been designed and tested for use in a diagnostic device. The scraper will be used to probe a proton beam in order to detect the formation of beam halo. Probing the proton beam exposes the scraper to high heat fluxes on the order of 610 kW/cm.
R. Valdiviez, null Dinh Nguyen, L. Earley, R. LaFave, F. Martinez, A. Rendon   +5 more
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Two-electron temperature model of a laser-driven implosion [PDF]

, 1985
The plasma ejected by a pellet irradiated with moderately intense laser light (Icrλ2 ∼1015 W cm−2 μm2, Icr and λ being intensity and wavelength) is analyzed.
Afanas’ev, Albritton, Braithwaite, Estabrook, Forslund, Gitomer, Goldsack, Kruer, Max, Mora, Ramis, Sanz, Sanz, Valeo   +13 more
core   +2 more sources

Anisotropic heating and parallel heat flux in electron-only magnetic reconnection with intense guide fields

Journal of Plasma Physics
Electron-only reconnection (E-REC) is a process recently observed in the Earth’s magnetosheath, where magnetic reconnection occurs at electron kinetic scales, and ions do not couple to the reconnection process. Electron-only reconnection is likely to have a significant impact on the energy conversion and dissipation of turbulence cascades at kinetic ...
Jincai Ren, Giuseppe Arrò, Maria Elena Innocenti, Giovanni Lapenta   +3 more
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source