Results 71 to 80 of about 159,270 (294)

Thermal breakage of window glass in room fires conditions - Analysis of some important parameters [PDF]

, 1997
In a compartment fire, the breakage and possible fallout of a window glass has a significant impact on the fire dynamics. The thermal breakage of glass depends on various parameters such as glass type, edge shading, edges conditions and constraints on ...
Siaka Dembele, Ricardo A.F. Rosario, Jennifer X. Wen, McJunkins, Mai, Pilette, Emmons, Barth, Pagni, Hassani, Pagni, Chow, Cuzzillo, Keski-Rahkonen, Pagni, Joshi, Sincaglia, Parry, Dembele, McGrattan, Dembele, Shields, Chow, Tofilo, Dembele, ANSYSInc, Weibull, Carlson, Gardon, Chandrupatla, Warren, Pilkington Plc, Harada, Mowrer, Xie, Lehman, Lamers   +36 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Powering Anomalous X-ray Pulsars by Neutron Star Cooling [PDF]

, 1997
Using recently calculated analytic models for the thermal structure of ultramagnetized neutron stars, we estimate the thermal fluxes from young ($t\sim 1000$ yr) ultramagnetized ($B \sim 10^{15}$ G) cooling neutron stars.
Blandford R. D., Hernquist L., Jeremy S. Heyl, Lars Hernquist, Potekhin A. Y., Shibanov Y. A., Thompson C., Van Paradijs J., Zavlin V. E.   +8 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Role of Atmospheric Rivers in Antarctic Sea Ice Variations

Geophysical Research Letters, 2023
Antarctic sea ice variations are affected by moisture and heat from low‐ and mid‐latitudes, more than 90% of which are transported by atmospheric rivers (ARs).
Kaixin Liang, Jinfei Wang, Hao Luo, Qinghua Yang   +3 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Rapid linear pyrolysis of composite solid propellant ingredients Final report [PDF]

Rapid linear pyrolysis of thermoplastic solid fuels by intense heat flux levels to simulate ...
Mc Alevy, R. F., III, Simon, D. R.
core   +1 more source

Magnetic flares in accretion disc coronae and the Spectral States of black hole candidates: the case of GX 339-4 [PDF]

, 1998
We present a model for the different X-ray spectral states displayed by Galactic Black Hole Candidates (GBHC). We discuss the physical and spectral implications for a magnetically structured corona in which magnetic flares result from reconnection of ...
Celotti, A., Di Matteo, T., Fabian, A. C.   +2 more
core   +3 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source