Results 71 to 80 of about 328,626 (335)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Effects of turbulence structure and urbanization on the heavy haze pollution process [PDF]
Atmospheric Chemistry and Physics, 2019 In this paper, an automated algorithm is developed, which is used to identify the spectral gap during the heavy haze pollution process, reconstruct acquired data, and obtain pure turbulence data.
Y. Ren +5 more
doaj +1 more source
Non-equilibrium of Ionization and the Detection of Hot Plasma in Nanoflare-heated Coronal Loops
, 2008 Impulsive nanoflares are expected to transiently heat the plasma confined in coronal loops to temperatures of the order of 10 MK. Such hot plasma is hardly detected in quiet and active regions, outside flares.
Fabio Reale +6 more
core +1 more source
Thermal breakage of window glass in room fires conditions - Analysis of some important parameters [PDF]
, 1997 In a compartment fire, the breakage and possible fallout of a window glass has a significant impact on the fire dynamics. The thermal breakage of glass depends on various parameters such as glass type, edge shading, edges conditions and constraints on ...
Siaka Dembele +36 more
core +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Exomoon Habitability and Tidal Evolution in Low-Mass Star Systems
, 2017 Discoveries of extrasolar planets in the habitable zone (HZ) of their parent star lead to questions about the habitability of massive moons orbiting planets in the HZ. Around low-mass stars, the HZ is much closer to the star than for Sun-like stars.
Armstrong, John C. +2 more
core +1 more source
Quiescent thermal emission from neutron stars in LMXBs [PDF]
, 2015 We monitored the quiescent thermal emission from neutron stars in low-mass X-ray binaries after active periods of intense activity in x-rays (outbursts).
Aguilera, Deborah N. +2 more
core +3 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Journal of Applied Engineering Science, 2020 The main purpose of this paper is to evaluate the structural response of composite steel-concrete eccentrically buckling-restrained braced frames (BRBFs). The finite element (FE) software ABAQUS is employed to nonlinearly analyse the BRBFs. Comparing the modelling and experimental test results validates the FE modelling method of the BRBF.
Polina Pronina, Ying Sun, Olga Tushavina
openaire +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source