Results 121 to 130 of about 3,650,514 (342)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Analyzing Peak-to-Average Power Ratio Characteristics in Multi-Channel Intensity Modulation and Direct Detection Flexible Transceivers Deploying Inverse Fast Fourier Transform/Fast Fourier Transform-Based Processing. [PDF]

Sensors (Basel), 2023
Chen L, Huang X, Jin W, Wang X, Yang G, Jiang M, Huang Y, Tang J.   +7 more
europepmc   +1 more source

Referencing in fiber optic sensing systems [PDF]

Different techniques to account for losses induced by the environment on signals in intensity modulation fiber optic sensing systems are described and ...
Adamovsky, Grigory
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

High-speed operation of optical exclusive OR circuit based on balanced detection and intensity modulation

The Journal of Engineering, 2015
We report the evaluated results of an optical exclusive OR (XOR) circuit for high-speed binary signals, which operates based on balanced detection and intensity modulation.
Koichi Takiguchi
doaj   +1 more source

Pretreatment synthetic magnetic resonance imaging predicts disease progression in nonmetastatic nasopharyngeal carcinoma after intensity modulation radiation therapy. [PDF]

Insights Imaging, 2023
Yang F, Wei H, Li X, Yu X, Zhao Y, Li L, Li Y, Xie L, Wang S, Lin M.   +9 more
europepmc   +1 more source

Cooling of a levitated nanoparticle with digital parametric feedback

, 2019
The motion control of a levitated nanoparticle plays a central role in optical levitation for fundamental studies and practical applications. Here, we presented a digital parametric feedback cooling based on switching between two trapping laser intensity
Guo, Guang-Can, Sun, Fang-Wen, Zheng, Yu
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

An optimized LSTM-based equalizer for 100 Gigabit/s-class short-range fiber-optic communications

AIMS Electronics and Electrical Engineering
Intensity modulation/direct detection (IM/DD) remains to be the preferred optical transmission scheme for short-range applications for its simplicity of application, inexpensiveness, and small footprint.
Vuong Quang Phuoc, Nguyen Van Dien, Ho Duc Tam Linh, Nguyen Van Tuan, Nguyen Van Hieu, Le Thai Son, Nguyen Tan Hung   +6 more
doaj   +1 more source

Solid-Electrolyte-Gated Graphene-Covered Metal-Insulator-Silicon-Insulator-Metal Waveguide With a Remarkably Large Modulation Depth

IEEE Access, 2019
Silicon photonic modulators are an essential element in providing fast and massive connectivity to the data-centric world. Ever-increasing data usage requires them to be smaller, faster, and easier to fabricate.
Yonghan Kim, Min-Suk Kwon
doaj   +1 more source