Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Efficacy and Safety of Simultaneous Integrated Boost Intensity-Modulation Radiation Therapy Combined with Systematic and Standardized Management for Esophageal Cancer. [PDF]
Front Surg, 2022 Deng W +6 more
europepmc +1 more source
Modulation Format and Digital Signal Processing for IM-DD Optics at Post-200G Era
Journal of Lightwave Technology200-Gb/s per lane intensity-modulation (IM) direct-detection (DD) optics are being commercialized to support 800G and 1.6T applications inside datacenters.
D. Che, X. Chen
semanticscholar +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Recovering the time dependence of the light intensity, the modulation frequency of which is greater than the cut-off frequency of a photodetector based on silicon with deep recombination centers. [PDF]
, 2018 E. V. Nikishin +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Outcome of Adenoid Cystic Carcinoma of Head and Neck After Postoperative Intensity Modulation Radiotherapy: A Single Institution Study. [PDF]
Cancer Manag Res, 2021 Xu P +7 more
europepmc +1 more source
Cross-phase modulation in rubidium-87
, 2009 This thesis explores the theoretical foundations of cross-phase modulation (XPM) between optical fields in the N-configuration atom. This is the process by which the refractive index experienced by one field can be modulated by controlling the intensity
Sinclair, Gary F.
core
Evaluation of Plan Robustness Using Hybrid Intensity-Modulated Radiotherapy (IMRT) and Volumetric Arc Modulation Radiotherapy (VMAT) for Left-Sided Breast Cancer [PDF]
, 2022 Zhen Ding +5 more
openalex +1 more source