Results 131 to 140 of about 3,283,391 (348)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
The Deleuzian Revolution: Ten Innovations in Difference and Repetition [PDF]
, 2020 Difference and Repetition might be said to have brought about a Deleuzian Revolution in philosophy comparable to Kant’s Copernican Revolution. Kant had denounced the three great terminal points of traditional metaphysics – self, world and God – as ...
Smith, Daniel W.
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Al Ibtida: Jurnal Pendidikan Guru MI, 2018 AbstrakBerdasarkan hasil observasi di kelas V SD Negeri Sunyaragi I diketahui bahwa siswa masih mengalami kesulitan dalam memahami suatu bacaan. Salah satu penyebabnya adalah guru cenderung menggunakan metode ceramah dan belum mengoptimalkan kemampuan ...
Patimah Patimah, Faisal Abdullah
doaj +1 more source
Penggunaan Metode Stad Dengan Media Artikel Berita Sebagai Upaya Peningkatan Keterampilan Membaca Intensif Siswa Kelas VIII E SMP Negeri 1 Kebonagung Tahun 2012/20131 [PDF]
, 2014 Based on the test results and exercises for the students of class VIII E , find the main idea skills through intensive reading students held low . Students do not understand the process and how to read that well , to be able to find the main idea through
Santosa, E. B. (Edy)
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
, 2017 Extensive Reading (ER) is a reading approach that aims to make covering large amounts of reading material enjoyable for language learners. Many experimental studies have showed the effectiveness of the ER approach on reading fluency, the ability to read ...
A. Park
semanticscholar +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Process-Oriented Parallel Programming with an Application to Data-Intensive Computing [PDF]
, 2014 We introduce process-oriented programming as a natural extension of object-oriented programming for parallel computing. It is based on the observation that every class of an object-oriented language can be instantiated as a process, accessible via a ...
Givelberg, Edward
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source