Results 51 to 60 of about 108,794 (260)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Reading approaches practiced in EFL classrooms: a narrative review and research agenda

Asian-Pacific Journal of Second and Foreign Language Education, 2022
Reading is an essential skill for students to perform effectively and successfully in any academic setting. This skill is vital for foreign language learners as it provides chances for students to be exposed to English in input-poor settings.
Zulfiquar Ali, Sarala Thulasi Palpanadan, Muhammad Mujtaba Asad, Prathamesh Churi, Ehsan Namaziandost   +4 more
doaj   +1 more source

Effect of Intensive Reading Strategy on Students’ Reading Comprehension

JOLADU: Journal of Language Education, 2023
This research was purposed to find out whether intensive reading strategy could give significance effect to the students’ reading comprehension. The location of this research was at SMA Negeri 1 Sei.Balai. The time that was alocated in this research was one month. This study was conducted in Experimental study.
openaire   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

EXTENSIVE AND INTENSIVE READING APPROACHES IN TEACHING ENGLISH READING

ALENA : Journal of Elementary Education, 2023
Artikel ini menjelaskan dasar konseptual dari pendekatan membaca ekstensif dan intensif dalam pengajaran membaca bahasa Inggris. Uraian dan ilustrasi tersebut berasal dari berbagai sumber, pengalaman, dan referensi. Pembahasan topik didasarkan pada hasil interpretasi dan kajian teoritis, yang kemudian dipadukan dengan hasil penelitian dan observasi ...
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Developing Students’ Reading Culture for Academic Reading Level through Metacognitive Strategies

Lingua Cultura, 2018
The development of reading culture for this academic level used the metacognitive strategies. This research was a case study in wihich the data sources were randomly drawn from various print sources by cutting off the core of the text to be analyzed. The
Pranowo pranowo
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A comparison of the impact of extensive and intensive reading approaches on the reading attitudes of secondary EFL learners

Studies in Second Language Learning and Teaching, 2020
Extensive reading (ER) which encourages second or foreign (L2) learners to engage in a great deal of reading, has long been recognized as an efficient approach in L2 reading pedagogy.
A Young Park
doaj