Results 71 to 80 of about 112,477 (255)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Development of Character-Based Intensive Reading Text Book in Elementary School

Jurnal Pendidikan Humaniora, 2015
Pengembangan Buku Teks Membaca Intensif Berbasis Karakter di Sekolah Dasar Abstract: The purpose of this study was (1) to develop instructional materials intensive reading of literary and non-literary class VI character-based, including materials and ...
Wisda Miftakhul Ulum
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Bringing Reading to Life. Tips for Vitalizing Reading in Primary School

RATE Issues
This article explores the way in which reading can be brought to life in the English lessons starting from the roles of the teacher in intensive reading and going on with examples of activities through which we can bring reading to life. The roles of the
Ligia-Daniela Botiza
doaj  

Literacy, Teens, Refugees, and Soccer

Refuge, 2013
This study examined the literacy development of teenage refugee boys in a one-month intensive summer literacy camp. Th e study intervention sought to abate literacy regression among language minority students in a suburban southern US city by combining ...
Eric Dwyer, Mary Lou McCloskey
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

EXPLORING INTENSIVE AND EXTENSIVE READING

This article examines the two major approaches to reading instruction—intensive and extensive reading—and explores how each contributes to language development. Intensive reading involves the close study of short, challenging texts with a focus on vocabulary, grammar, and detailed comprehension.
Abdurakhmonova, Zilola, Pardayeva, Robiya   +1 more
openaire   +3 more sources

Strengthening media literacy through intensive reading–listening skills in higher education: Information processing framework

Bahastra
Intensive reading and listening skills are things that need to be optimized for students of the Indonesian Language Education Study Program at UIN Kediri.
Nurul Dwi Lestari, Anwariyah Anwariyah, Gail Ekici   +2 more
doaj   +1 more source

Using a Suggested Program based on Intercultural Communicative Approach to Develop English Majors’ Intensive Reading Skills and Critical Cultural Awareness [PDF]

المجلة العلمية لکلية التربية - جامعة الوادى الجديد
The present study aimed to investigate the effectiveness of using a suggested program based on intercultural communicative approach in developing intensive reading skills and critical cultural awareness of English majors at Faculty of Education, New ...
محمد علي محمد قاسم
doaj   +1 more source