Results 81 to 90 of about 119,276 (254)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
BahastraIntensive reading and listening skills are things that need to be optimized for students of the Indonesian Language Education Study Program at UIN Kediri.
Nurul Dwi Lestari +2 more
doaj +1 more source
Using a Suggested Program based on Intercultural Communicative Approach to Develop English Majors’ Intensive Reading Skills and Critical Cultural Awareness [PDF]
المجلة العلمية لکلية التربية - جامعة الوادى الجديدThe present study aimed to investigate the effectiveness of using a suggested program based on intercultural communicative approach in developing intensive reading skills and critical cultural awareness of English majors at Faculty of Education, New ...
محمد علي محمد قاسم
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Time-Module Intensive Reading Program
, 2001 Time-Module Intensive Reading Program is the first speed-reading course ever accredited by the University of Paris. All general content developed in the Paris lectures and exercises are included herein.
Graham, Ross Lee,
core
Intensive Summer Intervention Drives Linear Growth of Reading Skill in Struggling Readers
Frontiers in Psychology, 2019 A major achievement of reading research has been the development of effective intervention programs for struggling readers. Most intervention studies employ a pre-post design, to examine efficacy, but this precludes the study of growth curves over the ...
Patrick M. Donnelly +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The effect of intensive reading strategy on students’ reading comprehension at grade VIII MTs N Batangtoru. [PDF]
, 2018 In this research, the researcher found that students’ mark in reading comprehension was unsatisfied. The students’ problem in reading comprehension were: 1) students’ did not have enough vocabularies, 2) students did not have enough facilities, and 3 ...
Panggabean, Yanti
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source