Results 81 to 90 of about 112,477 (255)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Revisiting Reading: Exploring an intensive reading pedagogy in adult literacy
Literacy and Numeracy Studies, 1970 Applied linguistic research into genres of written communication hashad a considerable impact in recent decades on the pedagogy of writing inall sectors of education in Australia, from early schooling to post-secondaryand workplace contexts (eg. Christie and Martin 1997). Attending to thesocial purpose of language and modelling and deconstructing texts
De Silva Joyce, Helen +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
THE EXCELLENCE OF EXTENSIVE AND INTENSIVE READING
ELTE Journal (English Language Teaching and Education), 2016 Abstract Extensive reading is reading in large numbers so that the reader can understand the material being read as well as a whole. Extensive Reading done with the following steps: a) survey the title page, preface, table of contents, and index; b) setting skim through the pages of text quickly.
openaire +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
EXPLANATION OF THE TERM "INTENSIVE READING"
Ushbu maqola intensiv o‘qish tushunchasini o‘rganadi. Intensiv o‘qish – matnni diqqat bilan va tahliliy tarzda tushunishga qaratilgan yondashuvdir. Maqolada intensiv o‘qish ta’riflanadi, uning maqsadlari va foydalari ko‘rib chiqiladi, shu jumladan matnni tushunish, lug‘at boyligini oshirish, grammatika aniqligi va tanqidiy fikrlash ko‘nikmalarini ...
Husinova, Malika, Abduraxmanova, Zilola
openaire +4 more sources
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source