Results 61 to 70 of about 119,276 (254)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

COMBINING EXTENSIVE AND INTENSIVE READING TO REINFORCE LANGUAGE LEARNING [PDF]

open access: yes, 2015
Reading large quantities of materials offers broad exposure to the target language hence extensive reading has been considered as an effective way to enhance language proficiency.
Tuğrul Mart, Çağrı
core  

The Effect of Intensive Reading Approach on Students’ Reading Comprehension

open access: yesLingual
The aim of the research was to determine that students' reading comprehension of narrative texts can be increased by using an intensive reading approach. The subject of this research are students at MA Ma’arif Miftahul Ulum Melirang Bungah Gresik.
Dewi Mutiara Al Lailiyah   +1 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

implementation of an intensive second language reading intervention program for Arabic L1 learners of English as a foreign language

open access: yes, 2022
The aim of this study was to investigate the effects of focused reading interventions on the eye movement patterns and reading scores of second language (L2) learners.
McCray, Gareth   +2 more
core   +1 more source

A comparison of the impact of extensive and intensive reading approaches on the reading attitudes of secondary EFL learners

open access: yesStudies in Second Language Learning and Teaching, 2020
Extensive reading (ER) which encourages second or foreign (L2) learners to engage in a great deal of reading, has long been recognized as an efficient approach in L2 reading pedagogy.
A Young Park
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

How Valid Is The DIBELS Oral Reading Fluency Test as an Indicator for Identifying At-Risk Readers and Documenting Their Progress?

open access: yes, 2012
The passage of the federal No Child Left Behind (NCLB) legislation in 2001, with its emphases on accountability, quality of instruction, and data-driven decision making, has created a national debate centered around the efficacy of a variety of practices
Foslin, Tim
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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