Results 81 to 90 of about 59,367 (258)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Exploring the reasons behind nurses' intentions to leave their hospital or profession: A cross-sectional survey

International Journal of Nursing Studies Advances
Background: Multiple factors can fuel nurses’ intention to leave their employing hospital or their profession. Job dissatisfaction and burnout are contributors to this decision. Sociodemographic and work context factors can also play a role in explaining
Marco Enea, Laura Maniscalco, Neeltje de Vries, Anke Boone, Olivia Lavreysen, Kamil Baranski, Silvana Miceli, Alessandra Savatteri, Walter Mazzucco, Santo Fruscione, Malgorzata Kowalska, Peter de Winter, Szymon Szemik, Lode Godderis, Domenica Matranga   +14 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Turnover intention among nurses in Iranian hospitals: a systematic review and meta-analysis

BMC Nursing
Background The turnover intention of nurses from their current positions have become a critical global public health challenge. In Iran, as a country facing with several of healthcare challenges, understanding the rate of nurses’ turnover intention is of
Alireza Hajizadeh, Edris Kakemam, Morteza Arab-Zozani, Zahra Najafpoor, Hossein Dargahi, Jalal Saeidpour   +5 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A global prevalence of turnover intention among doctors: a systematic review and meta-analysis

Scientific Reports
Turnover intention (TI) among doctors is a critical issue in healthcare systems worldwide, as it can lead to workforce shortages, increased workload for remaining staff, and negatively impact patient care.
Jingjing Wang, Hui Lv, Qin Qin, Hui Jiang, Wenjie Ren, Noorsuzana Mohd Shariff   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Effect of Job Insecurity to Organizational Commitment and Intention to Leave

Wacana: Jurnal Sosial dan Humaniora, 2019
The purpose of this research was to test and to analyze the influence of job insecurity towards organizational commitment and the intention to leave especially for employees working in notary offices.
Cindy Sandra Lumingkewas, Umar Nimran, Kusdi Raharjo, Hamidah Nayati Utami   +3 more
doaj