Results 81 to 90 of about 67,618 (299)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

THE RELATIONSHIP OF STAFF JOB SATISFACTION AND INTENTION TO LEAVE AT A HOSPITAL

open access: yesJurnal Administrasi Kesehatan Indonesia, 2019
Background: Job dissatisfaction arises as a result of a mismatch between expectation and reality in the employment conditions of employees in an organization. Job dissatisfaction can lead to the intention of to leave.
Nimas Ayu Mashuri   +1 more
doaj   +1 more source

An investigation into EFL instructors’ intention to leave and burnout: Exploring the mediating role of job satisfaction

open access: yesCogent Education, 2020
The purpose of this study is twofold. Firstly, to investigate if there are significant relationships between burnout, intention to leave, and job satisfaction among EFL instructors.
Linda Samadi   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Factors Influencing Employees' Intention to Leave Job

open access: yes, 2021
The purpose of this study was to investigate the factors affecting to employees' intention to quit job in private universities in Kabul, Afghanistan. For the purpose of the study, job satisfaction, job stress, person organization fit and organizational ...
DAWLAT KHAN AMARKHIL   +5 more
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Organizational Commitment and Intention to Leave Among Nurses: The Mediating Role of Moral Obligation

open access: yesInternational Journal of Management Studies, 2012
In today’s fast-paced economic competition, committ ed and loyal employees are important for the profi t-oriented organizations to gain and sustain their competitiveness.
Khatijah Omar   +3 more
doaj  

Prevalence and determinants of horizontal violence among nurses and its relationship with intention to leave

open access: yesDiscover Public Health
Background Horizontal violence is a destructive form of workplace violence that can result in inappropriate behaviors and ineffective care in nursing. Negative behaviors associated with peer violence reduce nurse retention.
Woldegebriel Gebregziabher Kahsay   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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