Results 101 to 110 of about 63,382 (353)
The FASEB Journal, 2008 For over half a century it has been conjectured that macromolecules form complex networks of functionally interacting components, and that the molecular mechanisms underlying most biological processes correspond to particular steady states adopted by such cellular networks. However, until recently, systems‐level theoretical conjectures remained largely
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Chemistry & Biology, 2008 MacBeath and colleagues (Kaushansky et al., 2008) use a protein array technology to find binding partners of ErbB4 in a genome-wide and quantitative fashion, shedding new light on how ErbB4 initiates cellular signaling events and why ErbB4 is not a potent oncogene.
Takahashi, Terry T., Li, Shuwei
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The Beclin 1 interactome [PDF]
Current Opinion in Cell Biology, 2010 The mammalian ortholog of yeast Atg6/Vps30, Beclin 1, is an essential autophagy protein that has been linked to diverse biological processes, including immunity, development, tumor suppression, lifespan extension, and protection against certain cardiac and neurodegenerative diseases.
Congcong, He, Beth, Levine
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p300 interactome transcription factors.
, 2013 Transcription factors in the p300 interactome which demonstrated significant regulation during A404 differentiation vs.
Philip S. Tsao (110770) +2 more
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Advanced Science, EarlyView.Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu +13 more
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Native Nanodiscs and the Convergence of Lipidomics, Metabolomics, Interactomics and Proteomics
Applied Sciences, 2019 The omics disciplines remain largely distinct sciences due to the necessity of separating molecular classes for different assays. For example, water-soluble and lipid bilayer-bound proteins and metabolites are usually studied separately.
Michael Overduin, Mansoore Esmaili
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The SARS-CoV-2 RNA interactome
bioRxiv, 2020 SARS-CoV-2 is an RNA virus whose success as a pathogen relies on its ability to repurpose host RNA-binding proteins (RBPs) to form its own RNA interactome. Here, we developed and applied a robust ribonucleoprotein capture protocol to uncover the SARS-CoV-
Sungyul Lee +8 more
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The human structural interactome.
, 2022 PPIs in the human structural interactome annotated with interface residue positions on canonical protein sequences from UniProt. (A) Y2H-SI. (B) Lit-SI. (XLSX)
Mohamed Ali Ghadie (4395727) +1 more
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Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity
Advanced Science, EarlyView.This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
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Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
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