Results 121 to 130 of about 53,983 (298)

Interactome networks

, 2007
Marc Vidal, Associate Professor of Genetics, Harvard Medical School presented a lecture at 11:00 AM, Tuesday, November 27, 2007, Klaus Advanced Computing Building, Room 1116WRuntime: 68:28 minutesFor over half a century it has been conjectured that ...
Vidal, Marc
core  

An empirical framework for binary interactome mapping. [PDF]

, 2008
Several attempts have been made to systematically map protein-protein interaction, or 'interactome', networks. However, it remains difficult to assess the quality and coverage of existing data sets.
Vazquez, Alexei, Cevik, S., Goh, K., Vidal, M., Sahalie, J.M., Borick, H., Lin, Chenwei, Sahalie, Julie M., Wanker, Erich E., Lin, C., Simonis, N., Goh, Kwang-Il., Heinzmann, K., David Szeto, Vinayagam, A., Barabasi, A.L., Vidal, Marc, Hill, David E, Hirozane-Kishikawa, T., Simon, Christophe, Sahalie, Julie M, de Smet, Anne-Sophie, Hao, T., Xin, X., Arunachalam Vinayagam, Cusick, M., Tavernier, J., Venkatesan, Kavitha, Ryan R Murray, Marc Vidal, Yildirim, M., Goh, Kwang-Il, Kathrin Heinzmann, Boone, Charles, Roth, Frederick P, Yu, Haiyuan, Murray, Ryan R, Tomoko Hirozane-Kishikawa, Barabási, Albert-László, Xiaofeng Xin, Zenkner, M., Cusick, M.E., Sahalie, J., Frederick P Roth, Yildirim, Muhammed A., Hill, D.E., Anne-Sophie de Smet, Gebreab, F., Szeto, D., Borick, Heather, Michael E Cusick, Zenkner, Martina, Lemmens, Irma, Julie M Sahalie, Timm, J., Vinayagam, Arunachalam, Boone, C., Dann, Elizabeth, Braun, P., Murray, Ryan R., Dricot, A., Irma Lemmens, Venkatesan, K., Roth, F.P., Wanker, Erich E, Alexei Vazquez, Rau, K., Hill, David E., Goh, K.I., Timm, Jan, Dann, E., Wanker, E., Martina Zenkner, Rual, J., Jean-François Rual, Simon, C., de Smet, A.S., David E Hill, Jan Timm, Hirozane-Kishikawa, Tomoko, Lalowski, Maciej, Cusick, Michael E., Heather Borick, Lalowski, M., Ulrich Stelzl, Niels Klitgord, Amélie Dricot, Roth, F., Barabási, A., Hao, Tong, Sebiha Cevik, Lemmens, I., Cusick, Michael E, Yildirim, M.A., Maciej Lalowski, Erich E Wanker, Murray, R.R., Klitgord, N., Nicolas Simonis, Hill, D., Pascal Braun, Rual, J.F., Klitgord, Niels, Kirstin Rau, Murray, R., Braun, Pascal, Stelzl, Ulrich, Christophe Simon, Simonis, Nicolas, Albert-László Barabási, Szeto, David, Tong Hao, Fana Gebreab, Smolyar, Alex, Dricot, Amélie, Heinzmann, Kathrin, Chenwei Lin, Kwang-Il Goh, de Smet, A., Wanker, E.E., Roth, Frederick P., Gebreab, Fana, Cevik, Sebiha, Kavitha Venkatesan, Rau, Kirstin, Xin, Xiaofeng, Elizabeth Dann, Jan Tavernier, Vazquez, A., Rual, Jean-François, Alex Smolyar, Haiyuan Yu, Yu, H., Yildirim, Muhammed A, Muhammed A Yildirim, Charles Boone, Stelzl, U., Tavernier, Jan, Smolyar, A.   +138 more
core   +1 more source

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

A complete interactome network map.

, 2014
A complete interactome network map.
Gopal Krishna R. Dhondalay (505277), Dong Ling Tong (598410), Graham R. Ball (505282), David J. Boocock (598411), Christophe Lemetre (505278)   +4 more
core   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Carbohydrate‐Directed Labeling Probes for UV‐Independent Chemoproteomic Profiling of Carbohydrate–Protein Interactions

Angewandte Chemie, EarlyView.
Modular carbohydrate‐directed labeling probes (CDLPs) convert weak carbohydrate–protein interactions into durable covalent tags in live cells without the need for multivalency or UV irradiation. Ligand binding triggers proximity‐enabled, glycan‐releasing acyl transfer to install a click handle for protein tagging and chemoproteomic profiling.
Matthew C. Russolillo, Wariya Nirachonkul, Nora Ross, Rahul M. Hedau, Zachary Clark, Michaella J. Rekowski, Michael P. Washburn, Mark P. Farrell   +7 more
wiley   +2 more sources

Ataxin-1 interactome

, 2018
Alphabetical listing of the ataxin-1[85Q] interactome in Neuro-2a cells identified by BioID and GFP-trap Pulldown ...
Marie A. Bogoyevitch (5977694), Sunyuan Zhang (5754746), Nicholas A. Williamson (255006)   +2 more
core   +1 more source

Prion‐Like Protein LENG8‐Mediated Nucleation Drives Stress Granule Assembly

Advanced Science, EarlyView.
LENG8 is a newly identified stress granule (SG) nucleator required for SG assembly. Following stress, nuclear LENG8 granules disassemble, allowing LENG8 to translocate into the cytoplasm and form independent nucleation foci. These foci fuse with canonical early G3BP1/TIA1 seeds via LENG8‐TIA1 binding to drive SG maturation.
Mingxing Zhang, Xin Wang, Yilan Teng, Zhicheng Wu, Jing Fan, Hongwen Zhu, Peng Dai   +6 more
wiley   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources